Watkins T - Search Results

1

Fibro-Scope V1.0.1: an artificial intelligence/neural network system for staging of nonalcoholic steatohepatitis.

Yamaguchi K, Shima T, Mitsumoto Y, Seko Y, Umemura A, Itoh Y, Nakajima A, Kaneko S, Harada K, Watkins T, Okanoue T. Yamaguchi K, et al. Among authors: watkins t. Hepatol Int. 2023 Jun;17(3):573-583. doi: 10.1007/s12072-022-10454-0. Epub 2022 Dec 21. Hepatol Int. 2023. PMID: 36542263

2

Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Younis IR, Hsueh CH, Nelson C, Billin AN, Yue MS, Xiao D, Watkins TR, Othman AA. Younis IR, et al. J Clin Pharmacol. 2023 Sep;63(9):1017-1025. doi: 10.1002/jcph.2260. Epub 2023 Jun 7. J Clin Pharmacol. 2023. PMID: 37128693

3

Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers.

Younis IR, Kirby BJ, Billin AN, Xiao D, Song Q, Watkins TR, Othman AA. Younis IR, et al. Clin Transl Sci. 2023 Mar;16(3):536-547. doi: 10.1111/cts.13469. Epub 2023 Jan 15. Clin Transl Sci. 2023. PMID: 36573450 Free PMC article. Clinical Trial.

4

AI-based histologic scoring enables automated and reproducible assessment of enrollment criteria and endpoints in NASH clinical trials.

Iyer JS, Pokkalla H, Biddle-Snead C, Carrasco-Zevallos O, Lin M, Shanis Z, Le Q, Juyal D, Pouryahya M, Pedawi A, Hoffman S, Elliott H, Leidal K, Myers RP, Chung C, Billin AN, Watkins TR, Resnick M, Wack K, Glickman J, Burt AD, Loomba R, Sanyal AJ, Montalto MC, Beck AH, Taylor-Weiner A, Wapinski I. Iyer JS, et al. medRxiv [Preprint]. 2023 Apr 25:2023.04.20.23288534. doi: 10.1101/2023.04.20.23288534. medRxiv. 2023. PMID: 37162870 Free PMC article. Preprint.

5

Pharmacokinetics and Safety of Firsocostat, an Acetyl-Coenzyme A Carboxylase Inhibitor, in Participants with Mild, Moderate, and Severe Hepatic Impairment.

Younis IR, Nelson C, Weber EJ, Qin AR, Watkins TR, Othman AA. Younis IR, et al. Among authors: watkins tr. J Clin Pharmacol. 2024 Mar 22. doi: 10.1002/jcph.2427. Online ahead of print. J Clin Pharmacol. 2024. PMID: 38520128

6

Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl-Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Weber E, Younis IR, Nelson C, Ding D, Qin A, Xiao D, Watkins TR, Othman AA. Weber E, et al. J Clin Pharmacol. 2023 May;63(5):560-568. doi: 10.1002/jcph.2206. Epub 2023 Feb 28. J Clin Pharmacol. 2023. PMID: 36700458 Clinical Trial.

7

Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor (FXR) Agonist.

Younis I, Weber E, Nelson C, Kirby BJ, Shen G, Xiao D, Watkins TR, Othman AA. Younis I, et al. Clin Pharmacokinet. 2023 Apr;62(4):609-621. doi: 10.1007/s40262-023-01214-w. Epub 2023 Mar 11. Clin Pharmacokinet. 2023. PMID: 36906733 Free PMC article.

8

Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies.

Reinisch W, Hellstrom W, Dolhain RJEM, Sikka S, Westhovens R, Mehta R, Ritter T, Seidler U, Golovchenko O, Simanenkov V, Garmish O, Jeka S, Moravcová R, Rajendran V, Le Brun FO, Arterburn S, Watkins TR, Besuyen R, Vanderschueren D. Reinisch W, et al. Among authors: watkins tr. Ann Rheum Dis. 2023 Aug;82(8):1049-1058. doi: 10.1136/ard-2023-224017. Epub 2023 May 3. Ann Rheum Dis. 2023. PMID: 37137672 Free PMC article. Clinical Trial.

9

Derivation and validation of a noninvasive prediction tool to identify pulmonary hypertension in patients with IPF: Evolution of the model FORD.

Nathan SD, Chandel A, Wang Y, Xu J, Shao L, Watkins TR, Diviney J, King CS, Han L. Nathan SD, et al. Among authors: watkins tr. J Heart Lung Transplant. 2024 Apr;43(4):547-553. doi: 10.1016/j.healun.2023.11.005. Epub 2023 Nov 17. J Heart Lung Transplant. 2024. PMID: 37979926 Free article. Clinical Trial.

10

Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation.

Weerakoon H, Mohamed A, Wong Y, Chen J, Senadheera B, Haigh O, Watkins TS, Kazakoff S, Mukhopadhyay P, Mulvenna J, Miles JJ, Hill MM, Lepletier A. Weerakoon H, et al. Among authors: watkins ts. NPJ Syst Biol Appl. 2024 Feb 28;10(1):21. doi: 10.1038/s41540-024-00346-4. NPJ Syst Biol Appl. 2024. PMID: 38418561 Free PMC article.

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