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Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth.
Furukawa S, Chatani M, Higashitani A, Higashibata A, Kawano F, Nikawa T, Numaga-Tomita T, Ogura T, Sato F, Sehara-Fujisawa A, Shinohara M, Shimazu T, Takahashi S, Watanabe-Takano H. Furukawa S, et al. Among authors: watanabe takano h. NPJ Microgravity. 2021 May 26;7(1):18. doi: 10.1038/s41526-021-00145-9. NPJ Microgravity. 2021. PMID: 34039989 Free PMC article. Review.
Gravity sensing in plant and animal cells.
Takahashi K, Takahashi H, Furuichi T, Toyota M, Furutani-Seiki M, Kobayashi T, Watanabe-Takano H, Shinohara M, Numaga-Tomita T, Sakaue-Sawano A, Miyawaki A, Naruse K. Takahashi K, et al. Among authors: watanabe takano h. NPJ Microgravity. 2021 Feb 8;7(1):2. doi: 10.1038/s41526-020-00130-8. NPJ Microgravity. 2021. PMID: 33558517 Free PMC article. Review.
Mechanical load regulates bone growth via periosteal Osteocrin.
Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N. Watanabe-Takano H, et al. Cell Rep. 2021 Jul 13;36(2):109380. doi: 10.1016/j.celrep.2021.109380. Cell Rep. 2021. PMID: 34260913 Free article.
Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.
Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, Mochizuki N, Inagaki N. Kanai Y, et al. J Clin Invest. 2017 Nov 1;127(11):4136-4147. doi: 10.1172/JCI94912. Epub 2017 Oct 9. J Clin Invest. 2017. PMID: 28990933 Free PMC article.
Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice.
Nishiguchi Y, Hata Y, Date R, Fujimoto D, Umemoto S, Kanki T, Yokoi H, Mori KP, Handa T, Watanabe-Takano H, Kanai Y, Yasoda A, Izumi Y, Kakizoe Y, Mochizuki N, Mukoyama M, Kuwabara T. Nishiguchi Y, et al. Among authors: watanabe takano h. Nephrol Dial Transplant. 2022 Feb 25;37(3):444-453. doi: 10.1093/ndt/gfab286. Nephrol Dial Transplant. 2022. PMID: 34610136 Free PMC article.
Cardiomyokines from the heart.
Chiba A, Watanabe-Takano H, Miyazaki T, Mochizuki N. Chiba A, et al. Among authors: watanabe takano h. Cell Mol Life Sci. 2018 Apr;75(8):1349-1362. doi: 10.1007/s00018-017-2723-6. Epub 2017 Dec 13. Cell Mol Life Sci. 2018. PMID: 29238844 Review.
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