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Endothelial Cell Redox Regulation of Ischemic Angiogenesis.
Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Cohen RA, et al. Among authors: watanabe y. J Cardiovasc Pharmacol. 2016 Jun;67(6):458-64. doi: 10.1097/FJC.0000000000000381. J Cardiovasc Pharmacol. 2016. PMID: 26927696 Free PMC article. Review.
Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization.
Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Murdoch CE, et al. Among authors: watanabe y. J Biol Chem. 2014 Mar 21;289(12):8633-44. doi: 10.1074/jbc.M113.517219. Epub 2014 Jan 30. J Biol Chem. 2014. PMID: 24482236 Free PMC article.
Endothelial cell-specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice.
Yura Y, Chong BSH, Johnson RD, Watanabe Y, Tsukahara Y, Ferran B, Murdoch CE, Behring JB, McComb ME, Costello CE, Janssen-Heininger YMW, Cohen RA, Bachschmid MM, Matsui R. Yura Y, et al. Among authors: watanabe y. FASEB J. 2019 Dec;33(12):14147-14158. doi: 10.1096/fj.201900786R. Epub 2019 Oct 26. FASEB J. 2019. PMID: 31647879 Free PMC article.
These data suggest that impaired ischemic vascularization does not necessarily associate with suppression of tumor growth, and that antiangiogenic therapies may be ineffective for melanoma tumors because of their ability to implement vasculogenic mimicry during hypoxia.-Yura, …
These data suggest that impaired ischemic vascularization does not necessarily associate with suppression of tumor growth, and that antiangi …
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