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Page 1
Discovery and characterization of a potent and selective EP4 receptor antagonist.
Schiffler MA, Chandrasekhar S, Fisher MJ, Harvey A, Kuklish SL, Wang XS, Warshawsky AM, York JS, Yu XP. Schiffler MA, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3176-8. doi: 10.1016/j.bmcl.2015.05.091. Epub 2015 Jun 4. Bioorg Med Chem Lett. 2015. PMID: 26091726
Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.
Blanco MJ, Vetman T, Chandrasekhar S, Fisher MJ, Harvey A, Chambers M, Lin C, Mudra D, Oskins J, Wang XS, Yu XP, Warshawsky AM. Blanco MJ, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2016 Feb 1;26(3):931-935. doi: 10.1016/j.bmcl.2015.12.057. Epub 2015 Dec 25. Bioorg Med Chem Lett. 2016. PMID: 26764191
Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.
Blanco MJ, Vetman T, Chandrasekhar S, Fisher MJ, Harvey A, Kuklish SL, Chambers M, Lin C, Mudra D, Oskins J, Wang XS, Yu XP, Warshawsky AM. Blanco MJ, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2016 May 1;26(9):2303-7. doi: 10.1016/j.bmcl.2016.03.041. Epub 2016 Mar 12. Bioorg Med Chem Lett. 2016. PMID: 27020304
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Kuklish SL, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland AJ, Gooding K, Harvey A, Hughes NE, Luz JG, Manninen PR, McGee JE, Navarro A, Norman BH, Partridge KM, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, York JS, Yu XP. Kuklish SL, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4824-4828. doi: 10.1016/j.bmcl.2016.08.023. Epub 2016 Aug 10. Bioorg Med Chem Lett. 2016. PMID: 27554445
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Partridge KM, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland A, Gooding K, Harvey A, Hughes NE, Kuklish SL, Luz JG, Manninen PR, McGee JE, Mudra DR, Navarro A, Norman BH, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, Weller JM, York JS, Yu XP. Partridge KM, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. doi: 10.1016/j.bmcl.2016.11.011. Epub 2016 Nov 7. Bioorg Med Chem Lett. 2017. PMID: 28190634
Analgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists.
Chandrasekhar S, Yu XP, Harvey AK, Oskins JL, Lin C, Wang X, Blanco MJ, Fisher MJ, Kuklish SL, Schiffler MA, Vetman T, Warshawsky AM, York JS, Bendele AM, Chambers MG. Chandrasekhar S, et al. Among authors: warshawsky am. Pharmacol Res Perspect. 2017 May 14;5(3):e00316. doi: 10.1002/prp2.316. eCollection 2017 Jun. Pharmacol Res Perspect. 2017. PMID: 28603634 Free PMC article.
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.
Shi Q, Canada EJ, Xu Y, Warshawsky AM, Etgen GJ, Broderick CL, Clutinger CK, Irwin LA, Laurila ME, Montrose-Rafizadeh C, Oldham BA, Wang M, Winneroski LL, Xie C, York JS, Yumibe NP, Zink RW, Mantlo N. Shi Q, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6744-9. doi: 10.1016/j.bmcl.2007.10.047. Epub 2007 Oct 18. Bioorg Med Chem Lett. 2007. PMID: 18029178
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
Hamdouchi C, Maiti P, Warshawsky AM, DeBaillie AC, Otto KA, Wilbur KL, Kahl SD, Patel Lewis A, Cardona GR, Zink RW, Chen K, Cr S, Lineswala JP, Neathery GL, Bouaichi C, Diseroad BA, Campbell AN, Sweetana SA, Adams LA, Cabrera O, Ma X, Yumibe NP, Montrose-Rafizadeh C, Chen Y, Miller AR. Hamdouchi C, et al. Among authors: warshawsky am. J Med Chem. 2018 Feb 8;61(3):934-945. doi: 10.1021/acs.jmedchem.7b01411. Epub 2018 Jan 5. J Med Chem. 2018. PMID: 29236497
Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
Henry JR, Li Y, Warshawsky AM, Brozinick JT, Hawkins ED, Misener EA, Briere DA, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Ajamie RT, Wilken B, Devanarayan V. Henry JR, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6293-7. doi: 10.1016/j.bmcl.2006.09.028. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17005393
15 results