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Resistance to antifungals that target CYP51.
Parker JE, Warrilow AG, Price CL, Mullins JG, Kelly DE, Kelly SL. Parker JE, et al. Among authors: warrilow ag. J Chem Biol. 2014 Aug 27;7(4):143-61. doi: 10.1007/s12154-014-0121-1. eCollection 2014 Oct. J Chem Biol. 2014. PMID: 25320648 Free PMC article. Review.
A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.
Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL. Martel CM, et al. Among authors: warrilow ag. Antimicrob Agents Chemother. 2010 Sep;54(9):3578-83. doi: 10.1128/AAC.00303-10. Epub 2010 Jun 14. Antimicrob Agents Chemother. 2010. PMID: 20547793 Free PMC article.
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