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The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.
Marttila P, Bonagas N, Chalkiadaki C, Stigsdotter H, Schelzig K, Shen J, Farhat CM, Hondema A, Albers J, Wiita E, Rasti A, Warpman Berglund U, Slipicevic A, Mortusewicz O, Helleday T. Marttila P, et al. Among authors: warpman berglund u. Mol Oncol. 2024 Mar 27. doi: 10.1002/1878-0261.13645. Online ahead of print. Mol Oncol. 2024. PMID: 38533616 Free article.
Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming.
Pateras IS, Williams C, Gianniou DD, Margetis AT, Avgeris M, Rousakis P, Legaki AI, Mirtschink P, Zhang W, Panoutsopoulou K, Delis AD, Pagakis SN, Tang W, Ambs S, Warpman Berglund U, Helleday T, Varvarigou A, Chatzigeorgiou A, Nordström A, Tsitsilonis OE, Trougakos IP, Gilthorpe JD, Frisan T. Pateras IS, et al. Among authors: warpman berglund u. J Transl Med. 2023 Mar 3;21(1):169. doi: 10.1186/s12967-023-03935-9. J Transl Med. 2023. PMID: 36869333 Free PMC article.
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.
Wallner O, Cázares-Körner A, Scaletti ER, Masuyer G, Bekkhus T, Visnes T, Mamonov K, Ortis F, Lundbäck T, Volkova M, Koolmeister T, Wiita E, Loseva O, Pandey M, Homan E, Benítez-Buelga C, Davies J, Scobie M, Warpman Berglund U, Kalderén C, Stenmark P, Helleday T, Michel M. Wallner O, et al. Among authors: warpman berglund u. ChemMedChem. 2023 Jan 3;18(1):e202200310. doi: 10.1002/cmdc.202200310. Epub 2022 Oct 13. ChemMedChem. 2023. PMID: 36128847 Free PMC article.
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia.
Sanjiv K, Calderón-Montaño JM, Pham TM, Erkers T, Tsuber V, Almlöf I, Höglund A, Heshmati Y, Seashore-Ludlow B, Nagesh Danda A, Gad H, Wiita E, Göktürk C, Rasti A, Friedrich S, Centio A, Estruch M, Våtsveen TK, Struyf N, Visnes T, Scobie M, Koolmeister T, Henriksson M, Wallner O, Sandvall T, Lehmann S, Theilgaard-Mönch K, Garnett MJ, Östling P, Walfridsson J, Helleday T, Warpman Berglund U. Sanjiv K, et al. Among authors: warpman berglund u. Cancer Res. 2021 Nov 15;81(22):5733-5744. doi: 10.1158/0008-5472.CAN-21-0061. Epub 2021 Sep 30. Cancer Res. 2021. PMID: 34593524 Free PMC article.
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.
Karsten S, Fiskesund R, Zhang XM, Marttila P, Sanjiv K, Pham T, Rasti A, Bräutigam L, Almlöf I, Marcusson-Ståhl M, Sandman C, Platzack B, Harris RA, Kalderén C, Cederbrant K, Helleday T, Warpman Berglund U. Karsten S, et al. Among authors: warpman berglund u. Cell Death Differ. 2022 Jan;29(1):246-261. doi: 10.1038/s41418-021-00854-4. Cell Death Differ. 2022. PMID: 34453118 Free PMC article.
A phenomics approach for antiviral drug discovery.
Rietdijk J, Tampere M, Pettke A, Georgiev P, Lapins M, Warpman-Berglund U, Spjuth O, Puumalainen MR, Carreras-Puigvert J. Rietdijk J, et al. Among authors: warpman berglund u. BMC Biol. 2021 Aug 2;19(1):156. doi: 10.1186/s12915-021-01086-1. BMC Biol. 2021. PMID: 34334126 Free PMC article.
MTH1 Inhibitors for the Treatment of Psoriasis.
Bivik Eding C, Köhler I, Verma D, Sjögren F, Bamberg C, Karsten S, Pham T, Scobie M, Helleday T, Warpman Berglund U, Enerbäck C. Bivik Eding C, et al. Among authors: warpman berglund u. J Invest Dermatol. 2021 Aug;141(8):2037-2048.e4. doi: 10.1016/j.jid.2021.01.026. Epub 2021 Mar 5. J Invest Dermatol. 2021. PMID: 33676948 Free article.
30 results