Waring MJ - Search Results

1

An analysis of the attrition of drug candidates from four major pharmaceutical companies.

Waring MJ, Arrowsmith J, Leach AR, Leeson PD, Mandrell S, Owen RM, Pairaudeau G, Pennie WD, Pickett SD, Wang J, Wallace O, Weir A. Waring MJ, et al. Nat Rev Drug Discov. 2015 Jul;14(7):475-86. doi: 10.1038/nrd4609. Epub 2015 Jun 19. Nat Rev Drug Discov. 2015. PMID: 26091267 Review.

2

Scope of on-DNA nucleophilic aromatic substitution on weakly-activated heterocyclic substrates for the synthesis of DNA-encoded libraries.

Castan IFSF, Madin A, Pairaudeau G, Waring MJ. Castan IFSF, et al. Among authors: waring mj. Bioorg Med Chem. 2022 Jun 1;63:116688. doi: 10.1016/j.bmc.2022.116688. Epub 2022 Mar 25. Bioorg Med Chem. 2022. PMID: 35430536 Free article.

3

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.

Luker T, Alcaraz L, Chohan KK, Blomberg N, Brown DS, Butlin RJ, Elebring T, Griffin AM, Guile S, St-Gallay S, Swahn BM, Swallow S, Waring MJ, Wenlock MC, Leeson PD. Luker T, et al. Among authors: waring mj. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5673-9. doi: 10.1016/j.bmcl.2011.07.074. Epub 2011 Jul 27. Bioorg Med Chem Lett. 2011. PMID: 21852131

4

High Fidelity Suzuki-Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants.

Hunter JH, Prendergast L, Valente LF, Madin A, Pairaudeau G, Waring MJ. Hunter JH, et al. Among authors: waring mj. Bioconjug Chem. 2020 Jan 15;31(1):149-155. doi: 10.1021/acs.bioconjchem.9b00838. Epub 2020 Jan 6. Bioconjug Chem. 2020. PMID: 31873005

5

Potential strategies for increasing drug-discovery productivity.

Cumming JG, Finlay MR, Giordanetto F, Hemmerling M, Lister T, Sanganee H, Waring MJ. Cumming JG, et al. Among authors: waring mj. Future Med Chem. 2014 Apr;6(5):515-27. doi: 10.4155/fmc.14.7. Future Med Chem. 2014. PMID: 24649955

6

A genetically selected cyclic peptide inhibitor of BCL6 homodimerization.

Osher EL, Castillo F, Elumalai N, Waring MJ, Pairaudeau G, Tavassoli A. Osher EL, et al. Among authors: waring mj. Bioorg Med Chem. 2018 Jul 15;26(11):3034-3038. doi: 10.1016/j.bmc.2018.03.012. Epub 2018 Mar 9. Bioorg Med Chem. 2018. PMID: 29555420

7

Lipophilicity in drug discovery.

Waring MJ. Waring MJ. Expert Opin Drug Discov. 2010 Mar;5(3):235-48. doi: 10.1517/17460441003605098. Expert Opin Drug Discov. 2010. PMID: 22823020

8

Functional Group Tolerance of a Micellar on-DNA Suzuki-Miyaura Cross-Coupling Reaction for DNA-Encoded Library Design.

Hunter JH, Potowski M, Stanway-Gordon HA, Madin A, Pairaudeau G, Brunschweiger A, Waring MJ. Hunter JH, et al. Among authors: waring mj. J Org Chem. 2021 Dec 17;86(24):17930-17935. doi: 10.1021/acs.joc.1c02259. Epub 2021 Nov 24. J Org Chem. 2021. PMID: 34816720

9

Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries.

Hunter JH, Anderson MJ, Castan IFSF, Graham JS, Salvini CLA, Stanway-Gordon HA, Crawford JJ, Madin A, Pairaudeau G, Waring MJ. Hunter JH, et al. Among authors: waring mj. Chem Sci. 2021 Jun 22;12(27):9475-9484. doi: 10.1039/d1sc03007h. eCollection 2021 Jul 14. Chem Sci. 2021. PMID: 34349922 Free PMC article.

10

The consequences of 'Brexit' for drug discovery and development, and the regulatory implications.

Golding BT, Waring MJ. Golding BT, et al. Among authors: waring mj. Expert Opin Drug Discov. 2018 Jul;13(7):583-585. doi: 10.1080/17460441.2018.1463215. Epub 2018 Apr 15. Expert Opin Drug Discov. 2018. PMID: 29634365 No abstract available.

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