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Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.
Wanrooij PH, Engqvist MKM, Forslund JME, Navarrete C, Nilsson AK, Sedman J, Wanrooij S, Clausen AR, Chabes A. Wanrooij PH, et al. Among authors: wanrooij s. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12466-12471. doi: 10.1073/pnas.1713085114. Epub 2017 Nov 6. Proc Natl Acad Sci U S A. 2017. PMID: 29109257 Free PMC article.
Oxidative DNA damage stalls the human mitochondrial replisome.
Stojkovič G, Makarova AV, Wanrooij PH, Forslund J, Burgers PM, Wanrooij S. Stojkovič G, et al. Among authors: wanrooij s, wanrooij ph. Sci Rep. 2016 Jul 1;6:28942. doi: 10.1038/srep28942. Sci Rep. 2016. PMID: 27364318 Free PMC article.
DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol.
Boldinova EO, Wanrooij PH, Shilkin ES, Wanrooij S, Makarova AV. Boldinova EO, et al. Among authors: wanrooij s, wanrooij ph. Int J Mol Sci. 2017 Jul 21;18(7):1584. doi: 10.3390/ijms18071584. Int J Mol Sci. 2017. PMID: 28754021 Free PMC article. Review.
PrimPol is required for replication reinitiation after mtDNA damage.
Torregrosa-Muñumer R, Forslund JME, Goffart S, Pfeiffer A, Stojkovič G, Carvalho G, Al-Furoukh N, Blanco L, Wanrooij S, Pohjoismäki JLO. Torregrosa-Muñumer R, et al. Among authors: wanrooij s. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11398-11403. doi: 10.1073/pnas.1705367114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073063 Free PMC article.
The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Forslund JME, Pfeiffer A, Stojkovič G, Wanrooij PH, Wanrooij S. Forslund JME, et al. Among authors: wanrooij s, wanrooij ph. PLoS Genet. 2018 Mar 30;14(3):e1007315. doi: 10.1371/journal.pgen.1007315. eCollection 2018 Mar. PLoS Genet. 2018. PMID: 29601571 Free PMC article.
40 results