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Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier.
Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov IA, Krueger M, Karram K, Moos S, Wanke F, Kurschus FC, Klein M, Cardoso S, Strauß J, Bolisetty S, Lühder F, Schwaninger M, Binder H, Bechman I, Bopp T, Agarwal A, Soares MP, Regen T, Waisman A. Hauptmann J, et al. Among authors: wanke f. Acta Neuropathol. 2020 Oct;140(4):549-567. doi: 10.1007/s00401-020-02187-x. Epub 2020 Jul 11. Acta Neuropathol. 2020. PMID: 32651669 Free PMC article.
NG2 plays a role in neuroinflammation but is not expressed by immune cells.
Kitic M, Karram K, Israel N, Yogev N, Lacher SM, Tang Y, Yigit H, Bauer J, Wanke F, Knezovic A, Trotter J, Kurschus FC, Waisman A. Kitic M, et al. Among authors: wanke f. Acta Neuropathol. 2017 Aug;134(2):325-327. doi: 10.1007/s00401-017-1735-5. Epub 2017 May 31. Acta Neuropathol. 2017. PMID: 28567522 No abstract available.
Subclinical CNS inflammation as response to a myelin antigen in humanized mice.
Zayoud M, El Malki K, Frauenknecht K, Trinschek B, Kloos L, Karram K, Wanke F, Georgescu J, Hartwig UF, Sommer C, Jonuleit H, Waisman A, Kurschus FC. Zayoud M, et al. Among authors: wanke f. J Neuroimmune Pharmacol. 2013 Sep;8(4):1037-47. doi: 10.1007/s11481-013-9466-4. Epub 2013 May 3. J Neuroimmune Pharmacol. 2013. PMID: 23640521
EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.
Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC. Wanke F, et al. Cell Rep. 2017 Jan 31;18(5):1270-1284. doi: 10.1016/j.celrep.2017.01.020. Cell Rep. 2017. PMID: 28147280 Free article.
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.
Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Müller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE, Waisman A. Lukas D, et al. Among authors: wanke f. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1480-E1489. doi: 10.1073/pnas.1615065114. Epub 2017 Feb 6. Proc Natl Acad Sci U S A. 2017. PMID: 28167776 Free PMC article.
Expression of IL-17F is associated with non-pathogenic Th17 cells.
Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC, Waisman A. Wanke F, et al. J Mol Med (Berl). 2018 Aug;96(8):819-829. doi: 10.1007/s00109-018-1662-5. Epub 2018 Jun 29. J Mol Med (Berl). 2018. PMID: 29959474
NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A. Lacher SM, et al. Among authors: wanke f. J Autoimmun. 2018 Nov;94:110-121. doi: 10.1016/j.jaut.2018.07.017. Epub 2018 Jul 29. J Autoimmun. 2018. PMID: 30061013
IL-17 controls central nervous system autoimmunity through the intestinal microbiome.
Regen T, Isaac S, Amorim A, Núñez NG, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Gálvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A. Regen T, et al. Among authors: wanke f. Sci Immunol. 2021 Feb 5;6(56):eaaz6563. doi: 10.1126/sciimmunol.aaz6563. Sci Immunol. 2021. PMID: 33547052
31 results