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Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer.
Gao S, Chen S, Han D, Wang Z, Li M, Han W, Besschetnova A, Liu M, Zhou F, Barrett D, Luong MP, Owiredu J, Liang Y, Ahmed M, Petricca J, Patalano S, Macoska JA, Corey E, Chen S, Balk SP, He HH, Cai C. Gao S, et al. Among authors: wang z. Nat Genet. 2020 Oct;52(10):1011-1017. doi: 10.1038/s41588-020-0681-7. Epub 2020 Aug 31. Nat Genet. 2020. PMID: 32868907 Free PMC article.
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1.
Wang Z, Petricca J, Liu M, Zhang S, Chen S, Li M, Besschetnova A, Patalano S, Venkataramani K, Siegfried KR, Macoska JA, Han D, Gao S, Vedadi M, Arrowsmith CH, He HH, Cai C. Wang Z, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2220472120. doi: 10.1073/pnas.2220472120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549269 Free PMC article.
Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression.
Besschetnova A, Han W, Liu M, Gao Y, Li M, Wang Z, Labaf M, Patalano S, Venkataramani K, Muriph RE, Macoska JA, Siegfried KR, Evans J, Balk SP, Gao S, Han D, Cai C. Besschetnova A, et al. Among authors: wang z. Cancer Res Commun. 2023 Aug 31;3(8):1716-1730. doi: 10.1158/2767-9764.CRC-23-0208. eCollection 2023 Aug. Cancer Res Commun. 2023. PMID: 37663929 Free PMC article.
Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs.
Han D, Labaf M, Zhao Y, Owiredu J, Zhang S, Patel K, Venkataramani K, Steinfeld JS, Han W, Li M, Liu M, Wang Z, Besschetnova A, Patalano S, Mulhearn MJ, Macoska JA, Yuan X, Balk SP, Nelson PS, Plymate SR, Gao S, Siegfried KR, Liu R, Stangis MM, Foxa G, Czernik PJ, Williams BO, Zarringhalam K, Li X, Cai C. Han D, et al. Among authors: wang z. J Clin Invest. 2024 Apr 30:e168649. doi: 10.1172/JCI168649. Online ahead of print. J Clin Invest. 2024. PMID: 38687617 Free article.
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