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Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.
Wang Y, Cai W, Cheng Y, Yang T, Liu Q, Zhang G, Meng Q, Han F, Huang Y, Zhou L, Xiang Z, Zhao YG, Xu Y, Cheng Z, Lu S, Wu Q, Xiang JN, Elliott JD, Leung S, Ren F, Lin X. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92. doi: 10.1021/acsmedchemlett.5b00122. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191367 Free PMC article.
The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities.
Li W, Long JD, Qian YY, Long Y, Xu XJ, Wang YJ, Shen Q, Wang ZN, Yang XC, Xiao L, Sun HP, Xu YL, Chen YY, Xie Q, Wang YH, Shao LM, Liu JG, Qiu ZB, Fu W. Li W, et al. Among authors: wang yh, wang yj, wang zn. ACS Chem Neurosci. 2017 Apr 19;8(4):766-776. doi: 10.1021/acschemneuro.6b00321. Epub 2017 Jan 19. ACS Chem Neurosci. 2017. PMID: 28033462
From RORγt Agonist to Two Types of RORγt Inverse Agonists.
Wang Y, Cai W, Tang T, Liu Q, Yang T, Yang L, Ma Y, Zhang G, Huang Y, Song X, Orband-Miller LA, Wu Q, Zhou L, Xiang Z, Xiang JN, Leung S, Shao L, Lin X, Lobera M, Ren F. Wang Y, et al. ACS Med Chem Lett. 2018 Jan 22;9(2):120-124. doi: 10.1021/acsmedchemlett.7b00476. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456799 Free PMC article.
Discovery of carbazole carboxamides as novel RORγt inverse agonists.
Huang Y, Yu M, Sun N, Tang T, Yu F, Song X, Xie Q, Fu W, Shao L, Wang Y. Huang Y, et al. Among authors: wang y. Eur J Med Chem. 2018 Mar 25;148:465-476. doi: 10.1016/j.ejmech.2018.02.050. Epub 2018 Feb 16. Eur J Med Chem. 2018. PMID: 29477887
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