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IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes.
Xu L, Zhou X, Wang W, Wang Y, Yin Y, Laan LJ, Sprengers D, Metselaar HJ, Peppelenbosch MP, Pan Q. Xu L, et al. Among authors: wang w, wang y. FASEB J. 2016 Oct;30(10):3352-3367. doi: 10.1096/fj.201600356R. Epub 2016 Jun 21. FASEB J. 2016. PMID: 27328944
We demonstrated that IRF1 effectively inhibits HEV replication through the activation of the JAK-STAT pathway, and the subsequent transcription of antiviral ISGs, but independent of IFN production.-Xu, L., Zhou, X., Wang, W., Wang, Y., Yin, Y., van der …
We demonstrated that IRF1 effectively inhibits HEV replication through the activation of the JAK-STAT pathway, and the subsequent transcript …
Modeling rotavirus infection and antiviral therapy using primary intestinal organoids.
Yin Y, Bijvelds M, Dang W, Xu L, van der Eijk AA, Knipping K, Tuysuz N, Dekkers JF, Wang Y, de Jonge J, Sprengers D, van der Laan LJ, Beekman JM, Ten Berge D, Metselaar HJ, de Jonge H, Koopmans MP, Peppelenbosch MP, Pan Q. Yin Y, et al. Among authors: wang y. Antiviral Res. 2015 Nov;123:120-31. doi: 10.1016/j.antiviral.2015.09.010. Epub 2015 Sep 25. Antiviral Res. 2015. PMID: 26408355
Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication.
Wang Y, Wang W, Xu L, Zhou X, Shokrollahi E, Felczak K, van der Laan LJ, Pankiewicz KW, Sprengers D, Raat NJ, Metselaar HJ, Peppelenbosch MP, Pan Q. Wang Y, et al. Among authors: wang w. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2834-48. doi: 10.1128/AAC.02700-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26926637 Free PMC article.
Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development.
Yin Y, Wang Y, Dang W, Xu L, Su J, Zhou X, Wang W, Felczak K, van der Laan LJ, Pankiewicz KW, van der Eijk AA, Bijvelds M, Sprengers D, de Jonge H, Koopmans MP, Metselaar HJ, Peppelenbosch MP, Pan Q. Yin Y, et al. Among authors: wang w, wang y. Antiviral Res. 2016 Sep;133:41-9. doi: 10.1016/j.antiviral.2016.07.017. Epub 2016 Jul 25. Antiviral Res. 2016. PMID: 27468950
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