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Dystrophin is a tumor suppressor in human cancers with myogenic programs.
Wang Y, Marino-Enriquez A, Bennett RR, Zhu M, Shen Y, Eilers G, Lee JC, Henze J, Fletcher BS, Gu Z, Fox EA, Antonescu CR, Fletcher CD, Guo X, Raut CP, Demetri GD, van de Rijn M, Ordog T, Kunkel LM, Fletcher JA. Wang Y, et al. Nat Genet. 2014 Jun;46(6):601-6. doi: 10.1038/ng.2974. Epub 2014 May 4. Nat Genet. 2014. PMID: 24793134 Free PMC article.
Cell cycle and dystrophin dysregulation in GIST.
Wang Y, Fletcher JA. Wang Y, et al. Cell Cycle. 2015;14(17):2713-4. doi: 10.1080/15384101.2015.1064676. Epub 2015 Jun 23. Cell Cycle. 2015. PMID: 26101897 Free PMC article. No abstract available.
MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.
Ravegnini G, Mariño-Enriquez A, Slater J, Eilers G, Wang Y, Zhu M, Nucci MR, George S, Angelini S, Raut CP, Fletcher JA. Ravegnini G, et al. Among authors: wang y. Mod Pathol. 2013 May;26(5):743-9. doi: 10.1038/modpathol.2012.203. Epub 2012 Dec 7. Mod Pathol. 2013. PMID: 23222489 Free article.
MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation.
Schaefer IM, Wang Y, Liang CW, Bahri N, Quattrone A, Doyle L, Mariño-Enríquez A, Lauria A, Zhu M, Debiec-Rychter M, Grunewald S, Hechtman JF, Dufresne A, Antonescu CR, Beadling C, Sicinska ET, van de Rijn M, Demetri GD, Ladanyi M, Corless CL, Heinrich MC, Raut CP, Bauer S, Fletcher JA. Schaefer IM, et al. Among authors: wang y. Nat Commun. 2017 Mar 8;8:14674. doi: 10.1038/ncomms14674. Nat Commun. 2017. PMID: 28270683 Free PMC article.
KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation.
Serrano C, Wang Y, Mariño-Enríquez A, Lee JC, Ravegnini G, Morgan JA, Bertagnolli MM, Beadling C, Demetri GD, Corless CL, Heinrich MC, Fletcher JA. Serrano C, et al. Among authors: wang y. J Clin Oncol. 2015 Aug 1;33(22):e93-6. doi: 10.1200/JCO.2013.48.7488. Epub 2014 Mar 31. J Clin Oncol. 2015. PMID: 24687822 Free PMC article. No abstract available.
Thyroid hormone inactivation in gastrointestinal stromal tumors.
Maynard MA, Marino-Enriquez A, Fletcher JA, Dorfman DM, Raut CP, Yassa L, Guo C, Wang Y, Dorfman C, Feldman HA, Frates MC, Song H, Jugo RH, Taguchi T, Hershman JM, Larsen PR, Huang SA. Maynard MA, et al. Among authors: wang y. N Engl J Med. 2014 Apr 3;370(14):1327-34. doi: 10.1056/NEJMoa1308893. N Engl J Med. 2014. PMID: 24693892 Free PMC article.
Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs).
Heinrich MC, Patterson J, Beadling C, Wang Y, Debiec-Rychter M, Dewaele B, Corless CL, Duensing A, Raut CP, Rubin B, Ordog T, van de Rijn M, Call J, Mühlenberg T, Fletcher JA, Bauer S. Heinrich MC, et al. Among authors: wang y. Clin Sarcoma Res. 2019 Mar 5;9:3. doi: 10.1186/s13569-019-0112-7. eCollection 2019. Clin Sarcoma Res. 2019. PMID: 30867899 Free PMC article.
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.
Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. Lee CH, et al. Among authors: wang y. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):929-34. doi: 10.1073/pnas.1115528109. Epub 2012 Jan 5. Proc Natl Acad Sci U S A. 2012. PMID: 22223660 Free PMC article.
Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors.
Pang Y, Xie F, Cao H, Wang C, Zhu M, Liu X, Lu X, Huang T, Shen Y, Li K, Jia X, Li Z, Zheng X, Wang S, He Y, Wang L, Fletcher JA, Wang Y. Pang Y, et al. Among authors: wang l, wang y, wang c, wang s. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22746-22753. doi: 10.1073/pnas.1914542116. Epub 2019 Oct 21. Proc Natl Acad Sci U S A. 2019. PMID: 31636198 Free PMC article.
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