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Antibacterial drug leads targeting isoprenoid biosynthesis.
Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Zhu W, et al. Among authors: wang k, wang y. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17. Proc Natl Acad Sci U S A. 2013. PMID: 23248302 Free PMC article.
Antibacterial drug leads: DNA and enzyme multitargeting.
Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E. Zhu W, et al. Among authors: wang y. J Med Chem. 2015 Feb 12;58(3):1215-27. doi: 10.1021/jm501449u. Epub 2015 Jan 22. J Med Chem. 2015. PMID: 25574764 Free PMC article.
Antiinfectives targeting enzymes and the proton motive force.
Feng X, Zhu W, Schurig-Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T, Kim BK, Crick DC, Cynamon M, McCammon JA, Gennis RB, Oldfield E. Feng X, et al. Among authors: wang y. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7073-82. doi: 10.1073/pnas.1521988112. Epub 2015 Dec 7. Proc Natl Acad Sci U S A. 2015. PMID: 26644565 Free PMC article.
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E. Desai J, et al. Among authors: wang k dr, wang y dr. ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30. ChemMedChem. 2016. PMID: 27571880 Free PMC article.
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. Zhang Y, et al. Among authors: wang k, wang y. ACS Med Chem Lett. 2012 Apr 3;3(5):402-406. doi: 10.1021/ml300038t. ACS Med Chem Lett. 2012. PMID: 22662288 Free PMC article.
Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads.
Sinko W, Wang Y, Zhu W, Zhang Y, Feixas F, Cox CL, Mitchell DA, Oldfield E, McCammon JA. Sinko W, et al. Among authors: wang y. J Med Chem. 2014 Jul 10;57(13):5693-701. doi: 10.1021/jm5004649. Epub 2014 Jun 24. J Med Chem. 2014. PMID: 24827744 Free PMC article.
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