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LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.
Li N, Rivéra-Bermúdez MA, Zhang M, Tejada J, Glasson SS, Collins-Racie LA, Lavallie ER, Wang Y, Chang KC, Nagpal S, Morris EA, Flannery CR, Yang Z. Li N, et al. Among authors: wang y. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9. doi: 10.1073/pnas.0911377107. Epub 2010 Feb 3. Proc Natl Acad Sci U S A. 2010. PMID: 20133709 Free PMC article.
Estrogen receptor beta is a novel therapeutic target for photoaging.
Chang KC, Wang Y, Oh IG, Jenkins S, Freedman LP, Thompson CC, Chung JH, Nagpal S. Chang KC, et al. Among authors: wang y. Mol Pharmacol. 2010 May;77(5):744-50. doi: 10.1124/mol.109.062877. Epub 2010 Jan 28. Mol Pharmacol. 2010. PMID: 20110405
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