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Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Jelínek M, Balušíková K, Daniel P, Němcová-Fürstová V, Kirubakaran P, Jaček M, Wei L, Wang X, Vondrášek J, Ojima I, Kovář J. Jelínek M, et al. Among authors: wang x. Toxicol Appl Pharmacol. 2018 May 15;347:79-91. doi: 10.1016/j.taap.2018.04.002. Epub 2018 Apr 4. Toxicol Appl Pharmacol. 2018. PMID: 29625142 Free PMC article.
Taxane anticancer agents: a patent perspective.
Ojima I, Lichtenthal B, Lee S, Wang C, Wang X. Ojima I, et al. Among authors: wang x, wang c. Expert Opin Ther Pat. 2016;26(1):1-20. doi: 10.1517/13543776.2016.1111872. Epub 2015 Dec 10. Expert Opin Ther Pat. 2016. PMID: 26651178 Free PMC article. Review.
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