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N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury.
Zhou H, Wang J, Jiang J, Stavrovskaya IG, Li M, Li W, Wu Q, Zhang X, Luo C, Zhou S, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. Zhou H, et al. Among authors: wang x, wang j. J Neurosci. 2014 Feb 19;34(8):2967-78. doi: 10.1523/JNEUROSCI.1948-13.2014. J Neurosci. 2014. PMID: 24553937 Free PMC article.
Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K, Cormier K, Bennett E, Browser RP, Day AL, Carlisle DL, Ferrante RJ, Wang X, Friedlander RM. Zhang Y, et al. Among authors: wang x. Neurobiol Dis. 2013 Jul;55:26-35. doi: 10.1016/j.nbd.2013.03.008. Epub 2013 Mar 26. Neurobiol Dis. 2013. PMID: 23537713 Free PMC article.
The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.
Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, Friedlander RM. Wang X, et al. Among authors: wang h. J Neurosci. 2011 Oct 12;31(41):14496-507. doi: 10.1523/JNEUROSCI.3059-11.2011. J Neurosci. 2011. PMID: 21994366 Free PMC article.
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