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Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.
Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL. Feuerstein GZ, et al. Among authors: wang x. J Cereb Blood Flow Metab. 2008 Jan;28(1):217-9. doi: 10.1038/sj.jcbfm.9600516. Epub 2007 Jun 20. J Cereb Blood Flow Metab. 2008. PMID: 17579658 Review.
Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of rapamycin inhibitor, temsirolimus, in a preclinical mammary carcinoma OncoMouse model: a translational medicine study in support for early clinical development.
Wang X, Zhan Y, Zhao L, Alvarez J, Chaudhary I, Zhou BB, Abraham RT, Feuerstein GZ. Wang X, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):421-9. doi: 10.1124/jpet.111.185249. Epub 2011 Aug 11. J Pharmacol Exp Ther. 2011. PMID: 21835932
Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation.
Wang X, Liu X, Zhan Y, Lavallie ER, Diblasio-Smith L, Collins-Racie L, Mounts WM, Rutkowski JL, Xu X, Goltsman I, Abassi Z, Winaver J, Feuerstein GZ. Wang X, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):820-9. doi: 10.1124/jpet.110.167635. Epub 2010 Jun 2. J Pharmacol Exp Ther. 2010. PMID: 20519551
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