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Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries.
Wang T, Wagner A, Gehwolf R, Yan W, Passini FS, Thien C, Weissenbacher N, Lin Z, Lehner C, Teng H, Wittner C, Zheng Q, Dai J, Ni M, Wang A, Papadimitriou J, Leys T, Tuan RS, Senck S, Snedeker JG, Tempfer H, Jiang Q, Zheng MH, Traweger A. Wang T, et al. Among authors: wang a. Sci Transl Med. 2021 Feb 24;13(582):eabe5738. doi: 10.1126/scitranslmed.abe5738. Sci Transl Med. 2021. PMID: 33627488
Bioreactor design for tendon/ligament engineering.
Wang T, Gardiner BS, Lin Z, Rubenson J, Kirk TB, Wang A, Xu J, Smith DW, Lloyd DG, Zheng MH. Wang T, et al. Among authors: wang a. Tissue Eng Part B Rev. 2013 Apr;19(2):133-46. doi: 10.1089/ten.TEB.2012.0295. Epub 2012 Nov 19. Tissue Eng Part B Rev. 2013. PMID: 23072472 Free PMC article. Review.
In vitro loading models for tendon mechanobiology.
Wang T, Chen P, Zheng M, Wang A, Lloyd D, Leys T, Zheng Q, Zheng MH. Wang T, et al. Among authors: wang a. J Orthop Res. 2018 Feb;36(2):566-575. doi: 10.1002/jor.23752. Epub 2017 Nov 2. J Orthop Res. 2018. PMID: 28960468 Free article. Review.
3D uniaxial mechanical stimulation induces tenogenic differentiation of tendon-derived stem cells through a PI3K/AKT signaling pathway.
Wang T, Thien C, Wang C, Ni M, Gao J, Wang A, Jiang Q, Tuan RS, Zheng Q, Zheng MH. Wang T, et al. Among authors: wang c, wang a. FASEB J. 2018 Sep;32(9):4804-4814. doi: 10.1096/fj.201701384R. Epub 2018 Mar 29. FASEB J. 2018. PMID: 29596022
Taken together, our study highlights the importance of appropriate mechanobiological stimulation in 3D cell niches on tendon-like tissue formation and demonstrates that uniaxial mechanical loading plays an essential role in tenogenic differentiation and tendon formation by activa …
Taken together, our study highlights the importance of appropriate mechanobiological stimulation in 3D cell niches on tendon-like tissue for …
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