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Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.
Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ Jr, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM. Chan YK, et al. Among authors: wang w, wang mk, wang sk. Sci Transl Med. 2021 Feb 10;13(580):eabd3438. doi: 10.1126/scitranslmed.abd3438. Sci Transl Med. 2021. PMID: 33568518 Free PMC article.
AAV cis-regulatory sequences are correlated with ocular toxicity.
Xiong W, Wu DM, Xue Y, Wang SK, Chung MJ, Ji X, Rana P, Zhao SR, Mai S, Cepko CL. Xiong W, et al. Among authors: wang sk. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5785-5794. doi: 10.1073/pnas.1821000116. Epub 2019 Mar 4. Proc Natl Acad Sci U S A. 2019. PMID: 30833387 Free PMC article.
Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.
Xiao Y, Muhuri M, Li S, Qin W, Xu G, Luo L, Li J, Letizia AJ, Wang SK, Chan YK, Wang C, Fuchs SP, Wang D, Su Q, Nahid MA, Church GM, Farzan M, Yang L, Wei Y, Desrosiers RC, Mueller C, Tai PW, Gao G. Xiao Y, et al. Among authors: wang sk, wang d, wang c. JCI Insight. 2019 May 21;5(13):e99052. doi: 10.1172/jci.insight.99052. JCI Insight. 2019. PMID: 31112525 Free PMC article.
Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa.
Wu DM, Ji X, Ivanchenko MV, Chung M, Piper M, Rana P, Wang SK, Xue Y, West E, Zhao SR, Xu H, Cicconet M, Xiong W, Cepko CL. Wu DM, et al. Among authors: wang sk. JCI Insight. 2021 Jan 25;6(2):e145029. doi: 10.1172/jci.insight.145029. JCI Insight. 2021. PMID: 33491671 Free PMC article.
Targeting Microglia to Treat Degenerative Eye Diseases.
Wang SK, Cepko CL. Wang SK, et al. Front Immunol. 2022 Feb 17;13:843558. doi: 10.3389/fimmu.2022.843558. eCollection 2022. Front Immunol. 2022. PMID: 35251042 Free PMC article. Review.
577 results