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VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
Lee C, Chen R, Sun G, Liu X, Lin X, He C, Xing L, Liu L, Jensen LD, Kumar A, Langer HF, Ren X, Zhang J, Huang L, Yin X, Kim J, Zhu J, Huang G, Li J, Lu W, Chen W, Liu J, Hu J, Sun Q, Lu W, Fang L, Wang S, Kuang H, Zhang Y, Tian G, Mi J, Kang BA, Narazaki M, Prodeus A, Schoonjans L, Ornitz DM, Gariepy J, Eelen G, Dewerchin M, Yang Y, Ou JS, Mora A, Yao J, Zhao C, Liu Y, Carmeliet P, Cao Y, Li X. Lee C, et al. Among authors: wang s. Signal Transduct Target Ther. 2023 Aug 18;8(1):305. doi: 10.1038/s41392-023-01539-9. Signal Transduct Target Ther. 2023. PMID: 37591843 Free PMC article.
VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis.
Huang D, Zhao C, Ju R, Kumar A, Tian G, Huang L, Zheng L, Li X, Liu L, Wang S, Ren X, Ye Z, Chen W, Xing L, Chen Q, Gao Z, Mi J, Tang Z, Wang B, Zhang S, Lee C, Li X. Huang D, et al. Among authors: wang s, wang b. Sci Rep. 2016 May 18;6:26059. doi: 10.1038/srep26059. Sci Rep. 2016. PMID: 27189805 Free PMC article.
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.
Zheng L, Zhao C, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, Ye Z, Huang L, Wang S, Ren X, Xing L, Chen W, Huang D, Gao Z, Zhang S, Lu W, Tang Z, Wang B, Ju R, Li X. Zheng L, et al. Among authors: wang s, wang b. Oncotarget. 2016 Nov 22;7(47):77902-77915. doi: 10.18632/oncotarget.12843. Oncotarget. 2016. PMID: 27788490 Free PMC article.
Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK.
Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, Chen Q, Xing L, Wang B, Cao Y, Sessa WC, Ju R, Liu Y, Li X. Jiang Y, et al. Among authors: wang s, wang b. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10737-10742. doi: 10.1073/pnas.1706394114. Epub 2017 Sep 18. Proc Natl Acad Sci U S A. 2017. PMID: 28923916 Free PMC article.
VEGF-B is a potent antioxidant.
Arjunan P, Lin X, Tang Z, Du Y, Kumar A, Liu L, Yin X, Huang L, Chen W, Chen Q, Ye Z, Wang S, Kuang H, Zhou L, Xu K, Chen X, Zeng H, Lu W, Cao Y, Liu Y, Zhao C, Li X. Arjunan P, et al. Among authors: wang s. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10351-10356. doi: 10.1073/pnas.1801379115. Epub 2018 Sep 24. Proc Natl Acad Sci U S A. 2018. PMID: 30249667 Free PMC article.
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