New Antibiotic Candidates against Helicobacter pylori.
Wang S, Cameron SA, Clinch K, Evans GB, Wu Z, Schramm VL, Tyler PC.
Wang S, et al.
J Am Chem Soc. 2015 Nov 18;137(45):14275-80. doi: 10.1021/jacs.5b06110. Epub 2015 Nov 9.
J Am Chem Soc. 2015.
PMID: 26494017
Free PMC article.
H. pylori uses an unusual pathway for menaquinone biosynthesis with 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) catalyzing an essential step. We validated MTAN as a target with a transition-state analogue of the enzyme [Wang, S.; Haapala …
H. pylori uses an unusual pathway for menaquinone biosynthesis with 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) …