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Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis.
Wang Q, Onuma K, Liu C, Wong H, Bloom MS, Elliott EE, Cao RR, Hu N, Lingampalli N, Sharpe O, Zhao X, Sohn DH, Lepus CM, Sokolove J, Mao R, Cisar CT, Raghu H, Chu CR, Giori NJ, Willingham SB, Prohaska SS, Cheng Z, Weissman IL, Robinson WH. Wang Q, et al. JCI Insight. 2019 Sep 19;4(18):e128616. doi: 10.1172/jci.insight.128616. JCI Insight. 2019. PMID: 31534047 Free PMC article.
Oral and topical boswellic acid attenuates mouse osteoarthritis.
Wang Q, Pan X, Wong HH, Wagner CA, Lahey LJ, Robinson WH, Sokolove J. Wang Q, et al. Osteoarthritis Cartilage. 2014 Jan;22(1):128-32. doi: 10.1016/j.joca.2013.10.012. Epub 2013 Nov 1. Osteoarthritis Cartilage. 2014. PMID: 24185109 Free PMC article.
Identification of a central role for complement in osteoarthritis.
Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Banda NK, Thurman JM, Gobezie R, Crow MK, Holers VM, Lee DM, Robinson WH. Wang Q, et al. Nat Med. 2011 Nov 6;17(12):1674-9. doi: 10.1038/nm.2543. Nat Med. 2011. PMID: 22057346 Free PMC article.
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