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The stress granule protein G3BP1 promotes pre-condensation of cGAS to allow rapid responses to DNA.
Zhao M, Xia T, Xing JQ, Yin LH, Li XW, Pan J, Liu JY, Sun LM, Wang M, Li T, Mao J, Han QY, Xue W, Cai H, Wang K, Xu X, Li T, He K, Wang N, Li AL, Zhou T, Zhang XM, Li WH, Li T. Zhao M, et al. Among authors: wang k, wang n, wang m. EMBO Rep. 2022 Jan 5;23(1):e53166. doi: 10.15252/embr.202153166. Epub 2021 Nov 15. EMBO Rep. 2022. PMID: 34779554 Free PMC article.
G3BP1 promotes DNA binding and activation of cGAS.
Liu ZS, Cai H, Xue W, Wang M, Xia T, Li WJ, Xing JQ, Zhao M, Huang YJ, Chen S, Wu SM, Wang X, Liu X, Pang X, Zhang ZY, Li T, Dai J, Dong F, Xia Q, Li AL, Zhou T, Liu ZG, Zhang XM, Li T. Liu ZS, et al. Among authors: wang x, wang m. Nat Immunol. 2019 Jan;20(1):18-28. doi: 10.1038/s41590-018-0262-4. Epub 2018 Dec 3. Nat Immunol. 2019. PMID: 30510222 Free PMC article.
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