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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.
Avery LB, Wang M, Kavosi MS, Joyce A, Kurz JC, Fan YY, Dowty ME, Zhang M, Zhang Y, Cheng A, Hua F, Jones HM, Neubert H, Polzer RJ, O'Hara DM. Avery LB, et al. Among authors: wang m. MAbs. 2016 Aug-Sep;8(6):1064-78. doi: 10.1080/19420862.2016.1193660. Epub 2016 May 27. MAbs. 2016. PMID: 27232760 Free PMC article.
Human FcRn Tissue Expression Profile and Half-Life in PBMCs.
Fan YY, Farrokhi V, Caiazzo T, Wang M, O'Hara DM, Neubert H. Fan YY, et al. Among authors: wang m. Biomolecules. 2019 Aug 15;9(8):373. doi: 10.3390/biom9080373. Biomolecules. 2019. PMID: 31443181 Free PMC article.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
Avery LB, Wade J, Wang M, Tam A, King A, Piche-Nicholas N, Kavosi MS, Penn S, Cirelli D, Kurz JC, Zhang M, Cunningham O, Jones R, Fennell BJ, McDonnell B, Sakorafas P, Apgar J, Finlay WJ, Lin L, Bloom L, O'Hara DM. Avery LB, et al. Among authors: wang m. MAbs. 2018 Feb/Mar;10(2):244-255. doi: 10.1080/19420862.2017.1417718. Epub 2018 Jan 29. MAbs. 2018. PMID: 29271699 Free PMC article.
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