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Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies.
Wang Y, Quan Q, Gleason C, Yu H, Peng L, Kang Y, Jiang L, Wu K, Pan J, Bao M, Zhu Q, Yi M, Fang M, Zheng Y, Qiu L, Xu B, Li X, Song J, Sun J, Zhang Z, Su Z, Lin J, Xie Y, Xu A, Song X, Huang C, Shen Z, Wang L, Song J. Wang Y, et al. Among authors: wang l. MAbs. 2023 Jan-Dec;15(1):2292305. doi: 10.1080/19420862.2023.2292305. Epub 2023 Dec 14. MAbs. 2023. PMID: 38095560 Free PMC article.
An Fc-Competent Anti-Human TIGIT Blocking Antibody Ociperlimab (BGB-A1217) Elicits Strong Immune Responses and Potent Anti-Tumor Efficacy in Pre-Clinical Models.
Chen X, Xue L, Ding X, Zhang J, Jiang L, Liu S, Hou H, Jiang B, Cheng L, Zhu Q, Zhang L, Zhou X, Ma J, Liu Q, Li Y, Ren Z, Jiang B, Song X, Song J, Jin W, Wei M, Shen Z, Liu X, Wang L, Li K, Zhang T. Chen X, et al. Among authors: wang l. Front Immunol. 2022 Feb 22;13:828319. doi: 10.3389/fimmu.2022.828319. eCollection 2022. Front Immunol. 2022. PMID: 35273608 Free PMC article.
Transbronchoscopic patient biopsy-derived xenografts as a preclinical model to explore chemorefractory-associated pathways and biomarkers for small-cell lung cancer.
Wang Z, Fu S, Zhao J, Zhao W, Shen Z, Wang D, Duan J, Bai H, Wan R, Yu J, Wang S, Chen H, Chen B, Wang L, Wang J. Wang Z, et al. Among authors: wang l, wang j, wang d, wang s. Cancer Lett. 2019 Jan;440-441:180-188. doi: 10.1016/j.canlet.2018.10.014. Epub 2018 Oct 19. Cancer Lett. 2019. PMID: 30347283
Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor.
Xiong Y, Guo Y, Liu Y, Wang H, Gong W, Liu Y, Wang X, Gao Y, Yu F, Su D, Wang F, Zhu Y, Zhao Y, Wu Y, Qin Z, Sun X, Ren B, Jiang B, Jin W, Shen Z, Tang Z, Song X, Wang L, Liu X, Zhou C, Jiang B. Xiong Y, et al. Among authors: wang h, wang x, wang f, wang l. Neoplasia. 2020 Sep;22(9):431-440. doi: 10.1016/j.neo.2020.06.009. Epub 2020 Jul 8. Neoplasia. 2020. PMID: 32652442 Free PMC article.
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models.
Jiang B, Zhang T, Deng M, Jin W, Hong Y, Chen X, Chen X, Wang J, Hou H, Gao Y, Gong W, Wang X, Li H, Zhou X, Feng Y, Zhang B, Jiang B, Lu X, Zhang L, Li Y, Song W, Sun H, Wang Z, Song X, Shen Z, Liu X, Li K, Wang L, Liu Y. Jiang B, et al. Among authors: wang x, wang l, wang j, wang z. Front Med. 2023 Dec;17(6):1170-1185. doi: 10.1007/s11684-023-0996-8. Epub 2023 Sep 25. Front Med. 2023. PMID: 37747585
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions.
Zhang T, Song X, Xu L, Ma J, Zhang Y, Gong W, Zhang Y, Zhou X, Wang Z, Wang Y, Shi Y, Bai H, Liu N, Yang X, Cui X, Cao Y, Liu Q, Song J, Li Y, Tang Z, Guo M, Wang L, Li K. Zhang T, et al. Among authors: wang l, wang z, wang y. Cancer Immunol Immunother. 2018 Jul;67(7):1079-1090. doi: 10.1007/s00262-018-2160-x. Epub 2018 Apr 23. Cancer Immunol Immunother. 2018. PMID: 29687231 Free PMC article.
Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Liu J, Li S, Wang Q, Feng Y, Xing H, Yang X, Guo Y, Guo Y, Sun H, Liu X, Yang S, Mei Z, Zhu Y, Cheng Z, Chen S, Xu M, Zhang W, Wan N, Wang J, Ma Y, Zhang S, Luan X, Xu A, Li L, Wang H, Yang X, Hong Y, Xue H, Yuan X, Hu N, Song X, Wang Z, Liu X, Wang L, Liu Y. Liu J, et al. Among authors: wang h, wang l, wang j, wang z, wang q. Blood. 2024 May 2;143(18):1825-1836. doi: 10.1182/blood.2023019706. Blood. 2024. PMID: 38211332 Free PMC article.
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