Wang L - Search Results

1

Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.

Wang L, Shao X, Zhong T, Wu Y, Xu A, Sun X, Gao H, Liu Y, Lan T, Tong Y, Tao X, Du W, Wang W, Chen Y, Li T, Meng X, Deng H, Yang B, He Q, Ying M, Rao Y. Wang L, et al. Among authors: wang w. Nat Chem Biol. 2021 May;17(5):567-575. doi: 10.1038/s41589-021-00742-5. Epub 2021 Mar 4. Nat Chem Biol. 2021. PMID: 33664520

2

Regioselective Annulation of Aryl Sulfonamides with Allenes through Cobalt-Promoted C-H Functionalization.

Lan T, Wang L, Rao Y. Lan T, et al. Among authors: wang l. Org Lett. 2017 Mar 3;19(5):972-975. doi: 10.1021/acs.orglett.6b03510. Epub 2017 Feb 23. Org Lett. 2017. PMID: 28229600

3

Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

Yang X, Chen XJ, Yang Z, Xi YB, Wang L, Wu Y, Yan YB, Rao Y. Yang X, et al. Among authors: wang l. J Med Chem. 2018 Oct 11;61(19):8693-8706. doi: 10.1021/acs.jmedchem.8b00705. Epub 2018 Sep 24. J Med Chem. 2018. PMID: 30153006

4

A chemical approach for global protein knockdown from mice to non-human primates.

Sun X, Wang J, Yao X, Zheng W, Mao Y, Lan T, Wang L, Sun Y, Zhang X, Zhao Q, Zhao J, Xiao RP, Zhang X, Ji G, Rao Y. Sun X, et al. Among authors: wang l, wang j. Cell Discov. 2019 Feb 5;5:10. doi: 10.1038/s41421-018-0079-1. eCollection 2019. Cell Discov. 2019. PMID: 30729032 Free PMC article.

5

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics.

Zong Y, Fang F, Meyer KJ, Wang L, Ni Z, Gao H, Lewis K, Zhang J, Rao Y. Zong Y, et al. Among authors: wang l. Nat Commun. 2019 Jul 22;10(1):3268. doi: 10.1038/s41467-019-11211-y. Nat Commun. 2019. PMID: 31332172 Free PMC article.

6

Design, synthesis, and biological evaluation of multiple targeting antimalarials.

Yang Y, Tang T, Li X, Michel T, Ling L, Huang Z, Mulaka M, Wu Y, Gao H, Wang L, Zhou J, Meunier B, Ke H, Jiang L, Rao Y. Yang Y, et al. Among authors: wang l. Acta Pharm Sin B. 2021 Sep;11(9):2900-2913. doi: 10.1016/j.apsb.2021.05.008. Epub 2021 May 20. Acta Pharm Sin B. 2021. PMID: 34589403 Free PMC article.

7

Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis.

Jiang SY, Yang X, Yang Z, Li JW, Xu MQ, Qu YX, Tang JJ, Li YF, Wang L, Shao YW, Meng XY, Hu H, Song BL, Rao Y, Qi W. Jiang SY, et al. Among authors: wang l. Hepatology. 2022 Nov;76(5):1466-1481. doi: 10.1002/hep.32381. Epub 2022 Apr 16. Hepatology. 2022. PMID: 35102596

8

CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses.

Chen Y, Cai Q, Pan C, Liu W, Li L, Liu J, Gao M, Li X, Wang L, Rao Y, Yang H, Cheng G. Chen Y, et al. Among authors: wang l. Cancer Immunol Res. 2022 Apr 1;10(4):525-539. doi: 10.1158/2326-6066.CIR-21-0806. Cancer Immunol Res. 2022. PMID: 35181784

9

Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation.

Wang L, Wu Y, Li Z, Lan T, Zhao X, Lv W, Shi F, Luo X, Rao Y, Cao Y. Wang L, et al. RSC Adv. 2021 Dec 3;11(61):38907-38914. doi: 10.1039/d1ra06648j. eCollection 2021 Nov 29. RSC Adv. 2021. PMID: 35493211 Free PMC article.

10

Chemistries of bifunctional PROTAC degraders.

Cao C, He M, Wang L, He Y, Rao Y. Cao C, et al. Among authors: wang l. Chem Soc Rev. 2022 Aug 15;51(16):7066-7114. doi: 10.1039/d2cs00220e. Chem Soc Rev. 2022. PMID: 35916511 Review.

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