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Antibacterial drug leads targeting isoprenoid biosynthesis.
Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Zhu W, et al. Among authors: wang k, wang y. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17. Proc Natl Acad Sci U S A. 2013. PMID: 23248302 Free PMC article.
Mechanism of action and inhibition of dehydrosqualene synthase.
Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E. Lin FY, et al. Among authors: wang k, wang ah. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21337-42. doi: 10.1073/pnas.1010907107. Epub 2010 Nov 23. Proc Natl Acad Sci U S A. 2010. PMID: 21098670 Free PMC article.
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. No JH, et al. Among authors: wang k. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4058-63. doi: 10.1073/pnas.1118215109. Epub 2012 Mar 5. Proc Natl Acad Sci U S A. 2012. PMID: 22392982 Free PMC article.
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E. Desai J, et al. Among authors: wang k dr, wang y dr. ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30. ChemMedChem. 2016. PMID: 27571880 Free PMC article.
Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins.
Liu YL, Guerra F, Wang K, Wang W, Li J, Huang C, Zhu W, Houlihan K, Li Z, Zhang Y, Nair SK, Oldfield E. Liu YL, et al. Among authors: wang w, wang k. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8558-63. doi: 10.1073/pnas.1121107109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586085 Free PMC article.
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. Zhang Y, et al. Among authors: wang k, wang y. ACS Med Chem Lett. 2012 Apr 3;3(5):402-406. doi: 10.1021/ml300038t. ACS Med Chem Lett. 2012. PMID: 22662288 Free PMC article.
37,182 results
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