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CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, Fontanillo C, Tran E, Contreras A, Ng SWK, Matyskiela M, Wang K, Chamberlain P, Cathers B, Carmichael J, Hansen J, Wang JCY, Minden MD, Fan J, Pierce DW, Pourdehnad M, Rolfe M, Lopez-Girona A, Dick JE, Lu G. Surka C, et al. Among authors: wang k, wang jcy. Blood. 2021 Feb 4;137(5):661-677. doi: 10.1182/blood.2020008676. Blood. 2021. PMID: 33197925 Free PMC article.
A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency.
Kaufmann KB, Garcia-Prat L, Liu Q, Ng SWK, Takayanagi SI, Mitchell A, Wienholds E, van Galen P, Cumbaa CA, Tsay MJ, Pastrello C, Wagenblast E, Krivdova G, Minden MD, Lechman ER, Zandi S, Jurisica I, Wang JCY, Xie SZ, Dick JE. Kaufmann KB, et al. Among authors: wang jcy. Blood. 2019 May 16;133(20):2198-2211. doi: 10.1182/blood-2018-10-881441. Epub 2019 Feb 22. Blood. 2019. PMID: 30796022 Free article.
A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia.
Ng SWK, Murphy T, King I, Zhang T, Mah M, Lu Z, Stickle N, Ibrahimova N, Arruda A, Mitchell A, Mai M, He R, Madala BS, Viswanatha DS, Dick JE, Chan S, Virtanen C, Minden MD, Mercer T, Stockley T, Wang JCY. Ng SWK, et al. Among authors: wang jcy. Blood Adv. 2022 Feb 8;6(3):1064-1073. doi: 10.1182/bloodadvances.2021005741. Blood Adv. 2022. PMID: 34872104 Free PMC article.
SIRPαFc treatment targets human acute myeloid leukemia stem cells.
Galkin O, McLeod J, Kennedy JA, Jin L, Mbong N, Wong M, Uger RA, Minden MD, Danska JS, Wang JCY. Galkin O, et al. Among authors: wang jcy. Haematologica. 2021 Jan 1;106(1):279-283. doi: 10.3324/haematol.2019.245167. Haematologica. 2021. PMID: 32054659 Free PMC article. No abstract available.
CD200 expression marks leukemia stem cells in human AML.
Ho JM, Dobson SM, Voisin V, McLeod J, Kennedy JA, Mitchell A, Jin L, Eppert K, Bader G, Minden MD, Dick JE, Wang JCY. Ho JM, et al. Among authors: wang jcy. Blood Adv. 2020 Nov 10;4(21):5402-5413. doi: 10.1182/bloodadvances.2020001802. Blood Adv. 2020. PMID: 33147339 Free PMC article.
Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
Xie SZ, Kaufmann KB, Wang W, Chan-Seng-Yue M, Gan OI, Laurenti E, Garcia-Prat L, Takayanagi SI, Ng SWK, Xu C, Zeng AGX, Jin L, McLeod J, Wagenblast E, Mitchell A, Kennedy JA, Liu Q, Boutzen H, Kleinau M, Jargstorf J, Holmes G, Zhang Y, Voisin V, Bader GD, Wang JCY, Hannun YA, Luberto C, Schroeder T, Minden MD, Dick JE. Xie SZ, et al. Among authors: wang w, wang jcy. Blood Cancer Discov. 2021 Jan 1;2(1):32-53. doi: 10.1158/2643-3230.BCD-20-0155. Epub 2020 Dec 1. Blood Cancer Discov. 2021. PMID: 33458693 Free PMC article.
Cancer stem cells: lessons from leukemia.
Wang JC, Dick JE. Wang JC, et al. Trends Cell Biol. 2005 Sep;15(9):494-501. doi: 10.1016/j.tcb.2005.07.004. Trends Cell Biol. 2005. PMID: 16084092 Review.
An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.
Chen WC, Yuan JS, Xing Y, Mitchell A, Mbong N, Popescu AC, McLeod J, Gerhard G, Kennedy JA, Bogdanoski G, Lauriault S, Perdu S, Merkulova Y, Minden MD, Hogge DE, Guidos C, Dick JE, Wang JC. Chen WC, et al. Cancer Res. 2016 Mar 1;76(5):1214-24. doi: 10.1158/0008-5472.CAN-15-2743. Epub 2016 Feb 1. Cancer Res. 2016. PMID: 26833125
106 results