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The structure of MgtE in the absence of magnesium provides new insights into channel gating.
Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M. Jin F, et al. Among authors: wang j. PLoS Biol. 2021 Apr 27;19(4):e3001231. doi: 10.1371/journal.pbio.3001231. eCollection 2021 Apr. PLoS Biol. 2021. PMID: 33905418 Free PMC article.
Druggable negative allosteric site of P2X3 receptors.
Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R, Hattori M, Yu Y. Wang J, et al. Among authors: wang y, wang r. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4939-4944. doi: 10.1073/pnas.1800907115. Epub 2018 Apr 19. Proc Natl Acad Sci U S A. 2018. PMID: 29674445 Free PMC article.
GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6.
Yang PL, Li XH, Wang J, Ma XF, Zhou BY, Jiao YF, Wang WH, Cao P, Zhu MX, Li PW, Xiao ZH, Li CZ, Guo CR, Lei YT, Yu Y. Yang PL, et al. Among authors: wang j, wang wh. J Biol Chem. 2021 Oct;297(4):101125. doi: 10.1016/j.jbc.2021.101125. Epub 2021 Aug 28. J Biol Chem. 2021. PMID: 34461094 Free PMC article.
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