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RNA buffers the phase separation behavior of prion-like RNA binding proteins.
Maharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann TM, Jahnel M, Marrone L, Chang YT, Sterneckert J, Tomancak P, Hyman AA, Alberti S. Maharana S, et al. Among authors: wang j. Science. 2018 May 25;360(6391):918-921. doi: 10.1126/science.aar7366. Epub 2018 Apr 12. Science. 2018. PMID: 29650702 Free PMC article.
ATP as a biological hydrotrope.
Patel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA. Patel A, et al. Among authors: wang j. Science. 2017 May 19;356(6339):753-756. doi: 10.1126/science.aaf6846. Science. 2017. PMID: 28522535
A User's Guide for Phase Separation Assays with Purified Proteins.
Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA. Alberti S, et al. Among authors: wang j. J Mol Biol. 2018 Nov 2;430(23):4806-4820. doi: 10.1016/j.jmb.2018.06.038. Epub 2018 Jun 23. J Mol Biol. 2018. PMID: 29944854 Free PMC article.
Protein condensates as aging Maxwell fluids.
Jawerth L, Fischer-Friedrich E, Saha S, Wang J, Franzmann T, Zhang X, Sachweh J, Ruer M, Ijavi M, Saha S, Mahamid J, Hyman AA, Jülicher F. Jawerth L, et al. Among authors: wang j. Science. 2020 Dec 11;370(6522):1317-1323. doi: 10.1126/science.aaw4951. Science. 2020. PMID: 33303613
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J. Marrone L, et al. Among authors: wang j. Acta Neuropathol. 2019 Jul;138(1):67-84. doi: 10.1007/s00401-019-01998-x. Epub 2019 Apr 1. Acta Neuropathol. 2019. PMID: 30937520 Free PMC article.
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Chang YT, Guck J, Honigmann A, Mahamid J, Hyman AA, Pappu RV, Alberti S, Franzmann TM. Guillén-Boixet J, et al. Among authors: wang j. Cell. 2020 Apr 16;181(2):346-361.e17. doi: 10.1016/j.cell.2020.03.049. Cell. 2020. PMID: 32302572 Free PMC article.
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain.
Boczek EE, Fürsch J, Niedermeier ML, Jawerth L, Jahnel M, Ruer-Gruß M, Kammer KM, Heid P, Mediani L, Wang J, Yan X, Pozniakovski A, Poser I, Mateju D, Hubatsch L, Carra S, Alberti S, Hyman AA, Stengel F. Boczek EE, et al. Among authors: wang j. Elife. 2021 Sep 6;10:e69377. doi: 10.7554/eLife.69377. Elife. 2021. PMID: 34487489 Free PMC article.
Predicting protein condensate formation using machine learning.
van Mierlo G, Jansen JRG, Wang J, Poser I, van Heeringen SJ, Vermeulen M. van Mierlo G, et al. Among authors: wang j. Cell Rep. 2021 Feb 2;34(5):108705. doi: 10.1016/j.celrep.2021.108705. Cell Rep. 2021. PMID: 33535034 Free article.
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