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Chimeric kinase ALK induces expression of NAMPT and selectively depends on this metabolic enzyme to sustain its own oncogenic function.
Zhang Q, Basappa J, Wang HY, Nunez-Cruz S, Lobello C, Wang S, Liu X, Chekol S, Guo L, Ziober A, Nejati R, Shestov A, Feldman M, Glickson JD, Turner SD, Blair IA, Van Dang C, Wasik MA. Zhang Q, et al. Among authors: wang hy, wang s. Leukemia. 2023 Dec;37(12):2436-2447. doi: 10.1038/s41375-023-02038-0. Epub 2023 Sep 29. Leukemia. 2023. PMID: 37773266
Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming.
Marzec M, Halasa K, Liu X, Wang HY, Cheng M, Baldwin D, Tobias JW, Schuster SJ, Woetmann A, Zhang Q, Turner SD, Ødum N, Wasik MA. Marzec M, et al. Among authors: wang hy. J Immunol. 2013 Dec 15;191(12):6200-7. doi: 10.4049/jimmunol.1300744. Epub 2013 Nov 11. J Immunol. 2013. PMID: 24218456 Free PMC article.
Metabolic Detection of Bruton's Tyrosine Kinase Inhibition in Mantle Cell Lymphoma Cells.
Lee SC, Shestov AA, Guo L, Zhang Q, Roman JC, Liu X, Wang HY, Pickup S, Nath K, Lu P, Hofbauer S, Mesaros C, Wang YL, Nelson DS, Schuster SJ, Blair IA, Glickson JD, Wasik MA. Lee SC, et al. Among authors: wang hy, wang yl. Mol Cancer Res. 2019 Jun;17(6):1365-1377. doi: 10.1158/1541-7786.MCR-18-0256. Epub 2019 Mar 12. Mol Cancer Res. 2019. PMID: 30862686 Free PMC article.
Induction of Transcriptional Inhibitor HES1 and the Related Repression of Tumor-Suppressor TXNIP Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase NPM-ALK.
Zhang Q, Wang HY, Nayak A, Nunez-Cruz S, Slupianek A, Liu X, Basappa J, Fan JS, Chekol S, Nejati R, Bogusz AM, Turner SD, Swaminathan K, Wasik MA. Zhang Q, et al. Among authors: wang hy. Am J Pathol. 2022 Aug;192(8):1186-1198. doi: 10.1016/j.ajpath.2022.05.005. Epub 2022 May 28. Am J Pathol. 2022. PMID: 35640677 Free PMC article.
ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia.
Basappa J, Citir M, Zhang Q, Wang HY, Liu X, Melnikov O, Yahya H, Stein F, Muller R, Traynor-Kaplan A, Schultz C, Wasik MA, Ptasznik A. Basappa J, et al. Among authors: wang hy. Heliyon. 2020 May 7;6(5):e03910. doi: 10.1016/j.heliyon.2020.e03910. eCollection 2020 May. Heliyon. 2020. PMID: 32420483 Free PMC article.
5,079 results