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mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.
Wang HY, MacDonald ML, Borgmann-Winter KE, Banerjee A, Sleiman P, Tom A, Khan A, Lee KC, Roussos P, Siegel SJ, Hemby SE, Bilker WB, Gur RE, Hahn CG. Wang HY, et al. Mol Psychiatry. 2020 Apr;25(4):750-760. doi: 10.1038/s41380-018-0234-y. Epub 2018 Sep 13. Mol Psychiatry. 2020. PMID: 30214040 Free PMC article.
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE. Talbot K, et al. Among authors: wang hy. J Clin Invest. 2012 Apr;122(4):1316-38. doi: 10.1172/JCI59903. J Clin Invest. 2012. PMID: 22476197 Free PMC article.
Brain insulin signaling and cerebrovascular disease in human postmortem brain.
Arvanitakis Z, Capuano AW, Wang HY, Schneider JA, Kapasi A, Bennett DA, Ahima RS, Arnold SE. Arvanitakis Z, et al. Among authors: wang hy. Acta Neuropathol Commun. 2021 Apr 15;9(1):71. doi: 10.1186/s40478-021-01176-9. Acta Neuropathol Commun. 2021. PMID: 33858515 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35109097
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.
Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM. Arnold SE, et al. Among authors: wang hy. Nat Rev Neurol. 2018 Mar;14(3):168-181. doi: 10.1038/nrneurol.2017.185. Epub 2018 Jan 29. Nat Rev Neurol. 2018. PMID: 29377010 Free PMC article. Review.
5,087 results