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TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: wang h. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy.
Wang H, Sun RQ, Camera D, Zeng XY, Jo E, Chan SM, Herbert TP, Molero JC, Ye JM. Wang H, et al. FASEB J. 2016 Jul;30(7):2549-56. doi: 10.1096/fj.201500119. Epub 2016 Mar 28. FASEB J. 2016. PMID: 27022162
Taken together, our findings provide evidence that Nedd4-2 is up-regulated in response to ER stress by the spliced form of X-box binding protein 1 and that this is important in the induction of an appropriate autophagic response.-Wang, H. Sun, R.-Q., Camera, D., Zen …
Taken together, our findings provide evidence that Nedd4-2 is up-regulated in response to ER stress by the spliced form of X-box binding pro …
Novel Therapies for Pneumonia-Associated Severe Asthma Phenotypes.
Papanicolaou A, Wang H, Satzke C, Vlahos R, Wilson N, Bozinovski S. Papanicolaou A, et al. Among authors: wang h. Trends Mol Med. 2020 Nov;26(11):1047-1058. doi: 10.1016/j.molmed.2020.07.006. Epub 2020 Aug 19. Trends Mol Med. 2020. PMID: 32828703 Review.
CSF3R/CD114 mediates infection-dependent transition to severe asthma.
Wang H, FitzPatrick M, Wilson NJ, Anthony D, Reading PC, Satzke C, Dunne EM, Licciardi PV, Seow HJ, Nichol K, Adcock IM, Chung KF, Anderson GP, Vlahos R, Wark P, Bozinovski S. Wang H, et al. J Allergy Clin Immunol. 2019 Feb;143(2):785-788.e6. doi: 10.1016/j.jaci.2018.10.001. Epub 2018 Oct 9. J Allergy Clin Immunol. 2019. PMID: 30312710 Free article. No abstract available.
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