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Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.
de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DAGB, Wanderley CWS, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC, Paula NM, Silva PCS, Fonseca FR, Aires L, Heck N, Starick MR, Queiroz-Junior CM, Santos FRS, de Souza FRO, Costa VV, Barroso SPC, Morrot A, Van Weyenbergh J, Sordi R, Alisson-Silva F, Cunha FQ, Rocha EL, Chollet-Martin S, Hurtado-Nedelec MM, Martin C, Burgel PR, Mansur DS, Maurici R, Macauley MS, Báfica A, Witko-Sarsat V, Spiller F. de Oliveira Formiga R, et al. Among authors: wanderley cws. Br J Pharmacol. 2023 Jun;180(11):1460-1481. doi: 10.1111/bph.16013. Epub 2023 Jan 13. Br J Pharmacol. 2023. PMID: 36526272 Free PMC article.
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19.
de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DAGB, Wanderley CWS, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC, Paula NM, Silva PCS, Fonseca FR, Aires L, Heck N, Starick MR, Queiroz-Junior CM, Santos FRS, de Souza FRO, Costa VV, Barroso SPC, Morrot A, Van Weyenbergh J, Sordi R, Alisson-Silva F, Cunha FQ, Rocha EL, Chollet-Martin S, Hurtado-Nedelec MM, Martin C, Burgel PR, Mansur DS, Maurici R, Macauley MS, Báfica A, Witko-Sarsat V, Spiller F. de Oliveira Formiga R, et al. Among authors: wanderley cws. bioRxiv [Preprint]. 2022 Oct 14:2020.11.12.379115. doi: 10.1101/2020.11.12.379115. bioRxiv. 2022. PMID: 33200130 Free PMC article. Preprint.
Paediatric sepsis survivors are resistant to sepsis-induced long-term immune dysfunction.
Colón DF, Wanderley CW, Turato WM, Borges VF, Franchin M, Castanheira FVS, Nascimento D, Prado D, Haruo Fernandes de Lima M, Volpon LC, Kavaguti SK, Carlotti AP, Carmona F, Franklin BS, Cunha TM, Alves-Filho JC, Cunha FQ. Colón DF, et al. Br J Pharmacol. 2024 Apr;181(8):1308-1323. doi: 10.1111/bph.16286. Epub 2024 Jan 11. Br J Pharmacol. 2024. PMID: 37990806
Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.
Bertheloot D, Wanderley CW, Schneider AH, Schiffelers LD, Wuerth JD, Tödtmann JM, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS. Bertheloot D, et al. EMBO Mol Med. 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415. Epub 2022 Apr 19. EMBO Mol Med. 2022. PMID: 35438238 Free PMC article.
α-Phellandrene, a cyclic monoterpene, attenuates inflammatory response through neutrophil migration inhibition and mast cell degranulation.
Siqueira HDS, Neto BS, Sousa DP, Gomes BS, da Silva FV, Cunha FVM, Wanderley CWS, Pinheiro G, Cândido AGF, Wong DVT, Ribeiro RA, Lima-Júnior RCP, Oliveira FA. Siqueira HDS, et al. Among authors: wanderley cws. Life Sci. 2016 Sep 1;160:27-33. doi: 10.1016/j.lfs.2016.07.008. Epub 2016 Jul 20. Life Sci. 2016. PMID: 27449945 Free article.
Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress.
Gomes BS, Neto BPS, Lopes EM, Cunha FVM, Araújo AR, Wanderley CWS, Wong DVT, Júnior RCPL, Ribeiro RA, Sousa DP, Venes R Medeiros J, Oliveira RCM, Oliveira FA. Gomes BS, et al. Among authors: wanderley cws. Chem Biol Interact. 2017 Aug 1;273:73-81. doi: 10.1016/j.cbi.2017.05.019. Epub 2017 May 27. Chem Biol Interact. 2017. PMID: 28559105 Free article.
25 results