Wan L - Search Results

1

ITCH as a potential therapeutic target in human cancers.

Yin Q, Wyatt CJ, Han T, Smalley KSM, Wan L. Yin Q, et al. Among authors: wan l. Semin Cancer Biol. 2020 Dec;67(Pt 2):117-130. doi: 10.1016/j.semcancer.2020.03.003. Epub 2020 Mar 10. Semin Cancer Biol. 2020. PMID: 32165318 Free PMC article. Review.

2

Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.

Wu F, Dai X, Gan W, Wan L, Li M, Mitsiades N, Wei W, Ding Q, Zhang J. Wu F, et al. Among authors: wan l. Cancer Lett. 2017 Jan 28;385:207-214. doi: 10.1016/j.canlet.2016.10.021. Epub 2016 Oct 22. Cancer Lett. 2017. PMID: 27780719 Free PMC article.

3

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W. Wan L, et al. Cancer Discov. 2017 Apr;7(4):424-441. doi: 10.1158/2159-8290.CD-16-0647. Epub 2017 Feb 7. Cancer Discov. 2017. PMID: 28174173 Free PMC article.

4

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

Chen M, Wan L, Zhang J, Zhang J, Mendez L, Clohessy JG, Berry K, Victor J, Yin Q, Zhu Y, Wei W, Pandolfi PP. Chen M, et al. Among authors: wan l. Nat Commun. 2018 Jan 15;9(1):159. doi: 10.1038/s41467-017-02272-y. Nat Commun. 2018. PMID: 29335436 Free PMC article.

5

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W. Wan L, et al. Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024. Mol Cell. 2018. PMID: 29351847 Free PMC article.

6

AMPK lifts the PRC2-implemented gene repression.

Han T, Yin Q, Wan L. Han T, et al. Among authors: wan l. Mol Cell Oncol. 2018 Apr 4;5(3):e1441632. doi: 10.1080/23723556.2018.1441632. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250895 Free PMC article.

7

Cycling for renewal: Cell cycle machinery maintains prostate cancer stem-like cells.

Han T, Yin Q, Wan L. Han T, et al. Among authors: wan l. EBioMedicine. 2019 Apr;42:24-25. doi: 10.1016/j.ebiom.2019.03.074. Epub 2019 Mar 28. EBioMedicine. 2019. PMID: 30930046 Free PMC article. No abstract available.

8

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy.

Emmons MF, Faião-Flores F, Sharma R, Thapa R, Messina JL, Becker JC, Schadendorf D, Seto E, Sondak VK, Koomen JM, Chen YA, Lau EK, Wan L, Licht JD, Smalley KSM. Emmons MF, et al. Among authors: wan l. Cancer Res. 2019 Jun 1;79(11):2947-2961. doi: 10.1158/0008-5472.CAN-19-0040. Epub 2019 Apr 15. Cancer Res. 2019. PMID: 30987999 Free PMC article.

9

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, Wan L. Yin Q, et al. Among authors: wan l. Nat Commun. 2019 Apr 23;10(1):1870. doi: 10.1038/s41467-019-09844-0. Nat Commun. 2019. PMID: 31015455 Free PMC article.

10

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis.

Han T, Jiang S, Zheng H, Yin Q, Xie M, Little MR, Yin X, Chen M, Song SJ, Beg AA, Pandolfi PP, Wan L. Han T, et al. Among authors: wan l. Nat Commun. 2019 Aug 16;10(1):3716. doi: 10.1038/s41467-019-11618-7. Nat Commun. 2019. PMID: 31420536 Free PMC article.

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