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Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility.
Schoenthaler M, Waltl L, Hasenoehrl T, Seher D, Lutz A, Aulinger L, Temml V, König S, Siller A, Braun DE, Garscha U, Werz O, Schuster D, Schennach H, Koeberle A, Matuszczak B. Schoenthaler M, et al. Among authors: waltl l. Bioorg Chem. 2023 Oct;139:106685. doi: 10.1016/j.bioorg.2023.106685. Epub 2023 Jun 28. Bioorg Chem. 2023. PMID: 37418786 Free article.
Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.
Rao Z, Caprioglio D, Gollowitzer A, Kretzer C, Imperio D, Collado JA, Waltl L, Lackner S, Appendino G, Muñoz E, Temml V, Werz O, Minassi A, Koeberle A. Rao Z, et al. Among authors: waltl l. Biochem Pharmacol. 2022 Sep;203:115202. doi: 10.1016/j.bcp.2022.115202. Epub 2022 Aug 3. Biochem Pharmacol. 2022. PMID: 35932797 Free article.
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.
Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A. Thürmer M, et al. Among authors: waltl l. Nat Commun. 2022 May 27;13(1):2982. doi: 10.1038/s41467-022-30374-9. Nat Commun. 2022. PMID: 35624087 Free PMC article.