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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells.
de Matos AM, Martins A, Man T, Evans D, Walter M, Oliveira MC, López Ó, Fernandez-Bolaños JG, Dätwyler P, Ernst B, Macedo MP, Contino M, Colabufo NA, Rauter AP. de Matos AM, et al. Among authors: walter m. Pharmaceuticals (Basel). 2019 Jun 21;12(2):98. doi: 10.3390/ph12020098. Pharmaceuticals (Basel). 2019. PMID: 31234364 Free PMC article.
Discovery and SAR studies of novel GlyT1 inhibitors.
Walter MW, Hoffman BJ, Gordon K, Johnson K, Love P, Jones M, Man T, Phebus L, Reel JK, Rudyk HC, Shannon H, Svensson K, Yu H, Valli MJ, Porter WJ. Walter MW, et al. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5233-8. doi: 10.1016/j.bmcl.2007.06.074. Epub 2007 Jun 30. Bioorg Med Chem Lett. 2007. PMID: 17629697
Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas.
Perry KW, Falcone JF, Fell MJ, Ryder JW, Yu H, Love PL, Katner J, Gordon KD, Wade MR, Man T, Nomikos GG, Phebus LA, Cauvin AJ, Johnson KW, Jones CK, Hoffmann BJ, Sandusky GE, Walter MW, Porter WJ, Yang L, Merchant KM, Shannon HE, Svensson KA. Perry KW, et al. Among authors: walter mw. Neuropharmacology. 2008 Oct;55(5):743-54. doi: 10.1016/j.neuropharm.2008.06.016. Epub 2008 Jun 17. Neuropharmacology. 2008. PMID: 18602930
Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter.
Cases-Thomas MJ, Masters JJ, Walter MW, Campbell G, Haughton L, Gallagher PT, Dobson DR, Mancuso V, Bonnier B, Giard T, Defrance T, Vanmarsenille M, Ledgard A, White C, Ouwerkerk-Mahadevan S, Brunelle FJ, Dezutter NA, Herbots CA, Lienard JY, Findlay J, Hayhurst L, Boot J, Thompson LK, Hemrick-Luecke S. Cases-Thomas MJ, et al. Among authors: walter mw. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2022-5. doi: 10.1016/j.bmcl.2005.12.061. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413778
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.
Dreyfus N, Myers JK, Badescu VO, de Frutos O, de la Puente ML, Ding C, Filla SA, Fynboe K, Gernert DL, Heinz BA, Hemrick-Luecke SK, Johnson KW, Johnson MP, López P, Love PL, Martin LJ, Masquelin T, McCoy MJ, Mendiola J, Morrow D, Muhlhauser M, Pascual G, Perun TJ, Pfeifer LA, Phebus LA, Richards SJ, Rincón JA, Seest EP, Shah J, Shaojuan J, Simmons RM, Stephenson GA, Tromiczak EG, Thompson LK, Walter MW, Weber WW, Zarrinmayeh H, Thomas CE, Joshi E, Iyengar S, Johansson AM. Dreyfus N, et al. Among authors: walter mw. ACS Med Chem Lett. 2013 May 7;4(6):560-4. doi: 10.1021/ml400049p. eCollection 2013 Jun 13. ACS Med Chem Lett. 2013. PMID: 24900709 Free PMC article.
2,791 results