Walsh DM - Search Results

1

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Among authors: walsh dm. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

2

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Walsh DM, et al. Nature. 2002 Apr 4;416(6880):535-9. doi: 10.1038/416535a. Nature. 2002. PMID: 11932745

3

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Klyubin I, et al. Among authors: walsh dm. Nat Med. 2005 May;11(5):556-61. doi: 10.1038/nm1234. Epub 2005 Apr 17. Nat Med. 2005. PMID: 15834427

4

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.

Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Klyubin I, et al. Among authors: walsh dm. J Neurosci. 2008 Apr 16;28(16):4231-7. doi: 10.1523/JNEUROSCI.5161-07.2008. J Neurosci. 2008. PMID: 18417702 Free PMC article.

5

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. Sala Frigerio C, et al. Among authors: walsh dm. Biochemistry. 2009 Nov 24;48(46):10894-904. doi: 10.1021/bi901237k. Biochemistry. 2009. PMID: 19821615 Free PMC article.

6

Cognitive effects of cell-derived and synthetically derived Aβ oligomers.

Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. Reed MN, et al. Among authors: walsh dm. Neurobiol Aging. 2011 Oct;32(10):1784-94. doi: 10.1016/j.neurobiolaging.2009.11.007. Epub 2010 Jan 19. Neurobiol Aging. 2011. PMID: 20031278 Free PMC article.

7

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM; Medical Research Council Cognitive Function and Ageing Study. Mc Donald JM, et al. Among authors: walsh dm. Brain. 2010 May;133(Pt 5):1328-41. doi: 10.1093/brain/awq065. Epub 2010 Apr 19. Brain. 2010. PMID: 20403962 Free PMC article.

8

Aberrant protein structure and diseases of the brain.

Welzel AT, Walsh DM. Welzel AT, et al. Among authors: walsh dm. Ir J Med Sci. 2011 Mar;180(1):15-22. doi: 10.1007/s11845-010-0606-z. Epub 2010 Oct 20. Ir J Med Sci. 2011. PMID: 20960238 Review.

9

Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain.

Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Shankar GM, et al. Among authors: walsh dm. Methods Mol Biol. 2011;670:33-44. doi: 10.1007/978-1-60761-744-0_3. Methods Mol Biol. 2011. PMID: 20967581

10

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Welzel AT, et al. Among authors: walsh dm. Biochemistry. 2014 Jun 24;53(24):3908-21. doi: 10.1021/bi5003053. Biochemistry. 2014. PMID: 24840308 Free PMC article.

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