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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL. Maurer MF, et al. Among authors: walse b. Nat Commun. 2022 Apr 4;13(1):1790. doi: 10.1038/s41467-022-29286-5. Nat Commun. 2022. PMID: 35379805 Free PMC article.
Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs.
Petruk G, Puthia M, Samsudin F, Petrlova J, Olm F, Mittendorfer M, Hyllén S, Edström D, Strömdahl AC, Diehl C, Ekström S, Walse B, Kjellström S, Bond PJ, Lindstedt S, Schmidtchen A. Petruk G, et al. Among authors: walse b. Nat Commun. 2023 Sep 29;14(1):6097. doi: 10.1038/s41467-023-41702-y. Nat Commun. 2023. PMID: 37773180 Free PMC article.
Publisher Correction: Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs.
Petruk G, Puthia M, Samsudin F, Petrlova J, Olm F, Mittendorfer M, Hyllén S, Edström D, Strömdahl AC, Diehl C, Ekström S, Walse B, Kjellström S, Bond PJ, Lindstedt S, Schmidtchen A. Petruk G, et al. Among authors: walse b. Nat Commun. 2023 Oct 13;14(1):6436. doi: 10.1038/s41467-023-42294-3. Nat Commun. 2023. PMID: 37833291 Free PMC article. No abstract available.
Discovery of selective small-molecule CD80 inhibitors.
Uvebrant K, da Graça Thrige D, Rosén A, Akesson M, Berg H, Walse B, Björk P. Uvebrant K, et al. Among authors: walse b. J Biomol Screen. 2007 Jun;12(4):464-72. doi: 10.1177/1087057107300464. Epub 2007 Apr 13. J Biomol Screen. 2007. PMID: 17435172
51 results