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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. Baglietto-Vargas D, et al. Among authors: walls kc. Nat Commun. 2021 Apr 23;12(1):2421. doi: 10.1038/s41467-021-22624-z. Nat Commun. 2021. PMID: 33893290 Free PMC article.
Lysosome dysfunction triggers Atg7-dependent neural apoptosis.
Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA. Walls KC, et al. J Biol Chem. 2010 Apr 2;285(14):10497-507. doi: 10.1074/jbc.M110.103747. Epub 2010 Feb 1. J Biol Chem. 2010. PMID: 20123985 Free PMC article.
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu Y, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J. Qiao L, et al. Among authors: walls kc. Mol Brain. 2008 Nov 21;1:17. doi: 10.1186/1756-6606-1-17. Mol Brain. 2008. PMID: 19021916 Free PMC article.
14 results