Walker S - Search Results

1

O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition.

Gondane A, Poulose N, Walker S, Mills IG, Itkonen HM. Gondane A, et al. Among authors: walker s. Glycobiology. 2022 Aug 18;32(9):751-759. doi: 10.1093/glycob/cwac038. Glycobiology. 2022. PMID: 35708495 Free PMC article.

2

HCF-1 is cleaved in the active site of O-GlcNAc transferase.

Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. Lazarus MB, et al. Among authors: walker s. Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990. Science. 2013. PMID: 24311690 Free PMC article.

3

Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.

Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Martin SES, et al. Among authors: walker s. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. doi: 10.1021/jacs.8b07328. Epub 2018 Oct 4. J Am Chem Soc. 2018. PMID: 30285435 Free PMC article.

4

High OGT activity is essential for MYC-driven proliferation of prostate cancer cells.

Itkonen HM, Urbanucci A, Martin SE, Khan A, Mathelier A, Thiede B, Walker S, Mills IG. Itkonen HM, et al. Among authors: walker s. Theranostics. 2019 Apr 12;9(8):2183-2197. doi: 10.7150/thno.30834. eCollection 2019. Theranostics. 2019. PMID: 31149037 Free PMC article.

5

CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation.

Itkonen HM, Poulose N, Walker S, Mills IG. Itkonen HM, et al. Among authors: walker s. Neoplasia. 2019 Jul;21(7):713-720. doi: 10.1016/j.neo.2019.05.001. Epub 2019 May 28. Neoplasia. 2019. PMID: 31151054 Free PMC article.

6

Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.

Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S. Joiner CM, et al. Among authors: walker s. J Am Chem Soc. 2019 Aug 21;141(33):12974-12978. doi: 10.1021/jacs.9b06061. Epub 2019 Aug 7. J Am Chem Soc. 2019. PMID: 31373491 Free PMC article.

7

Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9.

Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S. Itkonen HM, et al. Among authors: walker s. Mol Cancer Res. 2020 Oct;18(10):1512-1521. doi: 10.1158/1541-7786.MCR-20-0339. Epub 2020 Jul 1. Mol Cancer Res. 2020. PMID: 32611550 Free PMC article.

8

Protein Substrates Engage the Lumen of O-GlcNAc Transferase's Tetratricopeptide Repeat Domain in Different Ways.

Joiner CM, Hammel FA, Janetzko J, Walker S. Joiner CM, et al. Among authors: walker s. Biochemistry. 2021 Mar 23;60(11):847-853. doi: 10.1021/acs.biochem.0c00981. Epub 2021 Mar 12. Biochemistry. 2021. PMID: 33709700 Free PMC article.

9

Discovery of O-GlcNAc transferase inhibitors.

Gross BJ, Kraybill BC, Walker S. Gross BJ, et al. Among authors: walker s. J Am Chem Soc. 2005 Oct 26;127(42):14588-9. doi: 10.1021/ja0555217. J Am Chem Soc. 2005. PMID: 16231908

10

Structure of human O-GlcNAc transferase and its complex with a peptide substrate.

Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Lazarus MB, et al. Among authors: walker s. Nature. 2011 Jan 27;469(7331):564-7. doi: 10.1038/nature09638. Epub 2011 Jan 16. Nature. 2011. PMID: 21240259 Free PMC article.

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