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The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.
Shewell LK, Harvey RM, Higgins MA, Day CJ, Hartley-Tassell LE, Chen AY, Gillen CM, James DB, Alonzo F 3rd, Torres VJ, Walker MJ, Paton AW, Paton JC, Jennings MP. Shewell LK, et al. Among authors: walker mj. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5312-20. doi: 10.1073/pnas.1412703111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422425 Free PMC article.
Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.
Bohlmann L, De Oliveira DMP, El-Deeb IM, Brazel EB, Harbison-Price N, Ong CY, Rivera-Hernandez T, Ferguson SA, Cork AJ, Phan MD, Soderholm AT, Davies MR, Nimmo GR, Dougan G, Schembri MA, Cook GM, McEwan AG, von Itzstein M, McDevitt CA, Walker MJ. Bohlmann L, et al. Among authors: walker mj. mBio. 2018 Dec 11;9(6):e02391-18. doi: 10.1128/mBio.02391-18. mBio. 2018. PMID: 30538186 Free PMC article.
Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2.
Harbison-Price N, Ferguson SA, Heikal A, Taiaroa G, Hards K, Nakatani Y, Rennison D, Brimble MA, El-Deeb IM, Bohlmann L, McDevitt CA, von Itzstein M, Walker MJ, Cook GM. Harbison-Price N, et al. Among authors: walker mj. mSphere. 2020 Mar 18;5(2):e00157-20. doi: 10.1128/mSphere.00157-20. mSphere. 2020. PMID: 32188750 Free PMC article.
Antimicrobial Resistance in ESKAPE Pathogens.
De Oliveira DMP, Forde BM, Kidd TJ, Harris PNA, Schembri MA, Beatson SA, Paterson DL, Walker MJ. De Oliveira DMP, et al. Among authors: walker mj. Clin Microbiol Rev. 2020 May 13;33(3):e00181-19. doi: 10.1128/CMR.00181-19. Print 2020 Jun 17. Clin Microbiol Rev. 2020. PMID: 32404435 Free PMC article. Review.
647 results