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The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells.
Oroń M, Grochowski M, Jaiswar A, Legierska J, Jastrzębski K, Nowak-Niezgoda M, Kołos M, Kaźmierczak W, Olesiński T, Lenarcik M, Cybulska M, Mikula M, Żylicz A, Miączyńska M, Zettl K, Wiśniewski JR, Walerych D. Oroń M, et al. Among authors: walerych d. Cell Rep. 2022 Sep 27;40(13):111428. doi: 10.1016/j.celrep.2022.111428. Cell Rep. 2022. PMID: 36170818 Free article.
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer.
Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, Rajkowska K, Gaweda-Walerych K, Ingallina E, Tonelli C, Morelli MJ, Amato A, Eterno V, Zambelli A, Rosato A, Amati B, Wiśniewski JR, Del Sal G. Walerych D, et al. Nat Cell Biol. 2016 Aug;18(8):897-909. doi: 10.1038/ncb3380. Epub 2016 Jun 27. Nat Cell Biol. 2016. PMID: 27347849 Free article.
Hsp90 chaperones wild-type p53 tumor suppressor protein.
Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M. Walerych D, et al. J Biol Chem. 2004 Nov 19;279(47):48836-45. doi: 10.1074/jbc.M407601200. Epub 2004 Sep 9. J Biol Chem. 2004. PMID: 15358769 Free article.
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