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IMI European Lead Factory - democratizing access to high-throughput screening.
Jones PS, Boucharens S, McElroy SP, Morrison A, Honarnejad S, van Boeckel S, van den Hurk H, Basting D, Hüser J, Jaroch S, Ottow E, Benningshof J, Folmer RHA, Leemhuis F, Kramer-Verhulst PM, Nies VJM, Orrling KM, Rijnders T, Pfander C, Engkvist O, Pairaudeau G, Simpson PB, Ortholand JY, Roche D, Dömling A, Kühnert SM, Roevens PWM, van Vlijmen H, van Wanrooij EJA, Verbruggen C, Nussbaumer P, Ovaa H, van der Stelt M, Simonsen KB, Tagmose L, Waldmann H, Duffy J, Finsinger D, Jurzak M, Burgess-Brown NA, Lee WH, Rutjes FPJT, Haag H, Kallus C, Mors H, Dorval T, Lesur B, Ramon Olayo F, Hamza D, Jones G, Pearce C, Piechot A, Tzalis D, Clausen MH, Davis J, Derouane D, Vermeiren C, Kaiser M, Stockman RA, Barrault DV, Pannifer AD, Swedlow JR, Nelson AS, Orru RVA, Ruijter E, van Helden SP, Li VM, Vries T, de Vlieger JSB. Jones PS, et al. Among authors: waldmann h. Nat Rev Drug Discov. 2022 Apr;21(4):245-246. doi: 10.1038/d41573-021-00196-3. Nat Rev Drug Discov. 2022. PMID: 34907316 No abstract available.
Identification of siRNA delivery enhancers by a chemical library screen.
Gilleron J, Paramasivam P, Zeigerer A, Querbes W, Marsico G, Andree C, Seifert S, Amaya P, Stöter M, Koteliansky V, Waldmann H, Fitzgerald K, Kalaidzidis Y, Akinc A, Maier MA, Manoharan M, Bickle M, Zerial M. Gilleron J, et al. Among authors: waldmann h. Nucleic Acids Res. 2015 Sep 18;43(16):7984-8001. doi: 10.1093/nar/gkv762. Epub 2015 Jul 28. Nucleic Acids Res. 2015. PMID: 26220182 Free PMC article.
Illuminating Dark Chemical Matter Using the Cell Painting Assay.
Pahl A, Liu J, Patil S, Rezaei Adariani S, Schölermann B, Warmers J, Bonowski J, Koska S, Akbulut Y, Seitz C, Sievers S, Ziegler S, Waldmann H. Pahl A, et al. Among authors: waldmann h. J Med Chem. 2024 Apr 30. doi: 10.1021/acs.jmedchem.4c00160. Online ahead of print. J Med Chem. 2024. PMID: 38687818
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation.
Knyazeva A, Li S, Corkery DP, Shankar K, Herzog LK, Zhang X, Singh B, Niggemeyer G, Grill D, Gilthorpe JD, Gaetani M, Carlson LA, Waldmann H, Wu YW. Knyazeva A, et al. Among authors: waldmann h. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2317680121. doi: 10.1073/pnas.2317680121. Epub 2024 Apr 18. Proc Natl Acad Sci U S A. 2024. PMID: 38635626
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.
Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, Ehrler JHM, Hiesinger K, Thavam S, Janning P, Sievers S, Knapp S, Proschak E, Ziegler S, Waldmann H. Dötsch L, et al. Among authors: waldmann h. J Med Chem. 2024 Mar 28;67(6):4691-4706. doi: 10.1021/acs.jmedchem.3c02245. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38470246 Free PMC article.
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, Lampe P, Cheng X, Adariani SR, Winter GE, Waldmann H. Xue G, et al. Among authors: waldmann h. Nat Commun. 2023 Nov 30;14(1):7908. doi: 10.1038/s41467-023-43657-6. Nat Commun. 2023. PMID: 38036533 Free PMC article.
Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair.
Corkery D, Ursu A, Lucas B, Grigalunas M, Kriegler S, Oliva R, Dec R, Koska S, Pahl A, Sievers S, Ziegler S, Winter R, Wu YW, Waldmann H. Corkery D, et al. Among authors: waldmann h. Chembiochem. 2023 Dec 14;24(24):e202300579. doi: 10.1002/cbic.202300579. Epub 2023 Nov 7. Chembiochem. 2023. PMID: 37869939
1,021 results