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Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.
Marcinkowska M, Mordyl B, Fajkis-Zajaczkowska N, Siwek A, Karcz T, Gawalska A, Bucki A, Żmudzki P, Partyka A, Jastrzębska-Więsek M, Pomierny B, Walczak M, Smolik M, Pytka K, Mika K, Kotańska M, Kolaczkowski M. Marcinkowska M, et al. Among authors: walczak m. Eur J Med Chem. 2023 Feb 5;247:115071. doi: 10.1016/j.ejmech.2022.115071. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36603509
The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation.
Pytka K, Walczak M, Kij A, Rapacz A, Siwek A, Kazek G, Olczyk A, Gałuszka A, Waszkielewicz A, Marona H, Sapa J, Filipek B. Pytka K, et al. Among authors: walczak m. Eur J Pharmacol. 2015 Oct 5;764:537-546. doi: 10.1016/j.ejphar.2015.07.041. Epub 2015 Jul 22. Eur J Pharmacol. 2015. PMID: 26210317
Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.
Jastrzębska-Więsek M, Siwek A, Partyka A, Kołaczkowski M, Walczak M, Smolik M, Latacz G, Kieć-Kononowicz K, Wesołowska A. Jastrzębska-Więsek M, et al. Among authors: walczak m. Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan;391(1):37-49. doi: 10.1007/s00210-017-1431-y. Epub 2017 Oct 27. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29079874 Free PMC article.
Development, validation and application of a micro-liquid chromatography-tandem mass spectrometry based method for simultaneous quantification of selected protein biomarkers of endothelial dysfunction in murine plasma.
Suraj J, Kurpińska A, Olkowicz M, Niedzielska-Andres E, Smolik M, Zakrzewska A, Jasztal A, Sitek B, Chlopicki S, Walczak M. Suraj J, et al. Among authors: walczak m. J Pharm Biomed Anal. 2018 Feb 5;149:465-474. doi: 10.1016/j.jpba.2017.11.023. Epub 2017 Nov 10. J Pharm Biomed Anal. 2018. PMID: 29172146
HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.
Pytka K, Głuch-Lutwin M, Żmudzka E, Sałaciak K, Siwek A, Niemczyk K, Walczak M, Smolik M, Olczyk A, Gałuszka A, Śmieja J, Filipek B, Sapa J, Kołaczkowski M, Pańczyk K, Waszkielewicz A, Marona H. Pytka K, et al. Among authors: walczak m. Front Pharmacol. 2018 Oct 16;9:1146. doi: 10.3389/fphar.2018.01146. eCollection 2018. Front Pharmacol. 2018. PMID: 30410441 Free PMC article.
Quantitative measurement of selected protein biomarkers of endothelial dysfunction in plasma by micro-liquid chromatography-tandem mass spectrometry based on stable isotope dilution method.
Suraj J, Kurpińska A, Sternak M, Smolik M, Niedzielska-Andres E, Zakrzewska A, Sacha T, Kania A, Chlopicki S, Walczak M. Suraj J, et al. Among authors: walczak m. Talanta. 2019 Mar 1;194:1005-1016. doi: 10.1016/j.talanta.2018.10.067. Epub 2018 Oct 23. Talanta. 2019. PMID: 30609507
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers.
Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ. Hogendorf AS, et al. Among authors: walczak m. Eur J Med Chem. 2019 May 15;170:261-275. doi: 10.1016/j.ejmech.2019.03.017. Epub 2019 Mar 11. Eur J Med Chem. 2019. PMID: 30904783
802 results