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Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system.
Żelaszczyk D, Jakubczyk M, Pytka K, Rapacz A, Walczak M, Janiszewska P, Pańczyk K, Żmudzki P, Słoczyńska K, Marona H, Waszkielewicz AM. Żelaszczyk D, et al. Among authors: walczak m. Bioorg Med Chem Lett. 2019 Nov 1;29(21):126679. doi: 10.1016/j.bmcl.2019.126679. Epub 2019 Sep 9. Bioorg Med Chem Lett. 2019. PMID: 31537425
Anticonvulsant activity of some xanthone derivatives.
Marona H, Pekala E, Antkiewicz-Michaluk L, Walczak M, Szneler E. Marona H, et al. Among authors: walczak m. Bioorg Med Chem. 2008 Aug 1;16(15):7234-44. doi: 10.1016/j.bmc.2008.06.039. Epub 2008 Jun 25. Bioorg Med Chem. 2008. PMID: 18640843
The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation.
Pytka K, Walczak M, Kij A, Rapacz A, Siwek A, Kazek G, Olczyk A, Gałuszka A, Waszkielewicz A, Marona H, Sapa J, Filipek B. Pytka K, et al. Among authors: walczak m. Eur J Pharmacol. 2015 Oct 5;764:537-546. doi: 10.1016/j.ejphar.2015.07.041. Epub 2015 Jul 22. Eur J Pharmacol. 2015. PMID: 26210317
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Waszkielewicz AM, Gunia-Krzyżak A, Powroźnik B, Słoczyńska K, Pękala E, Walczak M, Bednarski M, Żesławska E, Nitek W, Marona H. Waszkielewicz AM, et al. Among authors: walczak m. Bioorg Med Chem. 2016 Apr 15;24(8):1793-810. doi: 10.1016/j.bmc.2016.03.006. Epub 2016 Mar 3. Bioorg Med Chem. 2016. PMID: 26988801
HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.
Pytka K, Głuch-Lutwin M, Żmudzka E, Sałaciak K, Siwek A, Niemczyk K, Walczak M, Smolik M, Olczyk A, Gałuszka A, Śmieja J, Filipek B, Sapa J, Kołaczkowski M, Pańczyk K, Waszkielewicz A, Marona H. Pytka K, et al. Among authors: walczak m. Front Pharmacol. 2018 Oct 16;9:1146. doi: 10.3389/fphar.2018.01146. eCollection 2018. Front Pharmacol. 2018. PMID: 30410441 Free PMC article.
Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists.
Partyka A, Zagórska A, Kotańska M, Walczak M, Jastrzębska-Więsek M, Knutelska J, Bednarski M, Głuch-Lutwin M, Mordyl B, Janiszewska P, Wesołowska A. Partyka A, et al. Among authors: walczak m. PLoS One. 2020 Aug 7;15(8):e0237196. doi: 10.1371/journal.pone.0237196. eCollection 2020. PLoS One. 2020. PMID: 32764777 Free PMC article.
802 results