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CD20-directed small modular immunopharmaceutical, TRU-015, depletes normal and malignant B cells.
Hayden-Ledbetter MS, Cerveny CG, Espling E, Brady WA, Grosmaire LS, Tan P, Bader R, Slater S, Nilsson CA, Barone DS, Simon A, Bradley C, Thompson PA, Wahl AF, Ledbetter JA. Hayden-Ledbetter MS, et al. Among authors: wahl af. Clin Cancer Res. 2009 Apr 15;15(8):2739-46. doi: 10.1158/1078-0432.CCR-08-1694. Epub 2009 Apr 7. Clin Cancer Res. 2009. PMID: 19351771
Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.
Nickerson-Nutter C, Tchistiakova L, Seth NP, Kasaian M, Sibley B, Olland S, Zollner R, Brady WA, Mohler KM, Baum P, Wahl A, Herber D, Vugmeyster Y, Wensel D, Wolfman NM, Gill D, Collins M, Dunussi-Joannopoulos K. Nickerson-Nutter C, et al. Rheumatology (Oxford). 2011 Jun;50(6):1033-44. doi: 10.1093/rheumatology/keq423. Epub 2011 Jan 21. Rheumatology (Oxford). 2011. PMID: 21258049 Free PMC article.
Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates.
Law CL, Cerveny CG, Gordon KA, Klussman K, Mixan BJ, Chace DF, Meyer DL, Doronina SO, Siegall CB, Francisco JA, Senter PD, Wahl AF. Law CL, et al. Among authors: wahl af. Clin Cancer Res. 2004 Dec 1;10(23):7842-51. doi: 10.1158/1078-0432.CCR-04-1028. Clin Cancer Res. 2004. PMID: 15585616
Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates.
Law CL, Gordon KA, Toki BE, Yamane AK, Hering MA, Cerveny CG, Petroziello JM, Ryan MC, Smith L, Simon R, Sauter G, Oflazoglu E, Doronina SO, Meyer DL, Francisco JA, Carter P, Senter PD, Copland JA, Wood CG, Wahl AF. Law CL, et al. Among authors: wahl af. Cancer Res. 2006 Feb 15;66(4):2328-37. doi: 10.1158/0008-5472.CAN-05-2883. Cancer Res. 2006. PMID: 16489038
61 results