Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

129 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Wagner SL, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44. doi: 10.1124/jpet.117.240861. Epub 2017 Apr 17. J Pharmacol Exp Ther. 2017. PMID: 28416568 Free PMC article.
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: wagner sl. Bioorg Med Chem. 2020 Nov 15;28(22):115734. doi: 10.1016/j.bmc.2020.115734. Epub 2020 Sep 1. Bioorg Med Chem. 2020. PMID: 33007551 Free PMC article.
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: wagner sl. J Exp Med. 2021 Apr 5;218(4):e20202560. doi: 10.1084/jem.20202560. J Exp Med. 2021. PMID: 33651103 Free PMC article.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Among authors: wagner sl. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.
129 results