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Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease.
Salcedo C, Pozo Garcia V, García-Adán B, Ameen AO, Gegelashvili G, Waagepetersen HS, Freude KK, Aldana BI. Salcedo C, et al. Among authors: waagepetersen hs. J Neurochem. 2023 Dec 8. doi: 10.1111/jnc.16014. Online ahead of print. J Neurochem. 2023. PMID: 38063257
Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons.
Aldana BI, Zhang Y, Lihme MF, Bak LK, Nielsen JE, Holst B, Hyttel P, Freude KK, Waagepetersen HS. Aldana BI, et al. Among authors: waagepetersen hs. Neurochem Int. 2017 Jun;106:48-61. doi: 10.1016/j.neuint.2017.02.010. Epub 2017 Feb 24. Neurochem Int. 2017. PMID: 28237843
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.
Salcedo C, Wagner A, Andersen JV, Vinten KT, Waagepetersen HS, Schousboe A, Freude KK, Aldana BI. Salcedo C, et al. Among authors: waagepetersen hs. Neurochem Res. 2021 Oct;46(10):2676-2686. doi: 10.1007/s11064-021-03276-3. Epub 2021 Mar 12. Neurochem Res. 2021. PMID: 33710537
Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease.
Salcedo C, Andersen JV, Vinten KT, Pinborg LH, Waagepetersen HS, Freude KK, Aldana BI. Salcedo C, et al. Among authors: waagepetersen hs. Front Aging Neurosci. 2021 Sep 17;13:736580. doi: 10.3389/fnagi.2021.736580. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34603012 Free PMC article.
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.
Andersen JV, Skotte NH, Christensen SK, Polli FS, Shabani M, Markussen KH, Haukedal H, Westi EW, Diaz-delCastillo M, Sun RC, Kohlmeier KA, Schousboe A, Gentry MS, Tanila H, Freude KK, Aldana BI, Mann M, Waagepetersen HS. Andersen JV, et al. Among authors: waagepetersen hs. Cell Death Dis. 2021 Oct 16;12(11):954. doi: 10.1038/s41419-021-04237-y. Cell Death Dis. 2021. PMID: 34657143 Free PMC article.
169 results